PURPOSE To report an anti-epiligrin cicatricial pemphigoid (AECP) patient with severe ocular involvement and to provide a practical approach to distinguishing AECP patients from those with other subepidermal blistering diseases. METHODS Techniques included direct and indirect immunofluorescence microscopy, Western blot and immunoprecipitation studies, as well as interdisciplinary examinations...

As manifestações oculares que podem ocorrer em pacientes com doenças reumáticas e algumas das opções terapêuticas atuais têm sido objeto de publicações científicas. Vale lembrar que a incidência de doenças sistêmicas em uveíte chega a 40% e que em grande parte as uveítes são causadas pelas doenças reumáticas. Medicações que incluem corticosteróides, imunossupressores e agentes biológicos, utili...

We report a case of eczema herpeticum with unilateral ocular involvement in a 16-year-old boy. The patient has had a mild form of atopic dermatitis (AD) since early childhood. Why AD patients are prone to herpes simplex virus (HSV) infections is still unclear. Ocular pathologic findings in these cases are rarely reported.

hrombotic thrombocytopenic purpura (TTP) is an uncommon blood syndrome characterized by a pentad of symptoms including hemolytic anemia on a microangiopathic basis, thrombocytopenia with consequently severe hemorrhagic diathesis, neurologic changes of varying severity and/or impaired renal function. Bleeding usually involves mainly the skin and mucosae, but the gastroenteric, urogenital, centra...

Topical acyclovir has been found in 15 out of 18 patients to control, without recurrences and in an appreciably shorter time than if steroids were used, keratoconjunctivitis induced by herpes zoster. Once steroids were started, recurrences occurred during withdrawal of steroids or after they had been stopped.

Oculodermal melanocytosis (ODM) is a congenital melanocytic hyperpigmentation of the face and ocular tissues. The eponym naevus of Ota as described by Otal has been used interchangeably with ODM and ocular melanosis (OM) in many reported cases. The original definition by Ota included patients with and without ocular involvement. For these reasons, we will refer to the term oculodermal melanocyt...