Administration of fresh leaves of Ocimum sanctum (Tulsi) mixed as 1 g and 2 g in 100 gms of diet given for four weeks, brought about significant changes in the lipid profile of normal albino rabbits. This resulted in significant lowering in serum total cholesterol, triglyceride, phospholipid and LDL-cholesterol levels and significant increase in the HDL-cholesterol and total faecal sterol conte...

The dietary nutritional management influences the rearing and commercial parameters of the silkworm. When silkworms were fed with mulberry leaves fortified with aqueous leaf extract of O. sanctum in the second instar, a positive response with respect to larval and commercial parameters were noticed. Highest larval weight in three instar viz third (1.341g/10 worms),fourth(5.434g/10),while in the...

Aqueous and methonol ic ex t rac t o f Ocimum sanc tum were p repared f rom a i r dr ied , powdered aer ia l pa r t s o f the p lan t . The p lan t mate r ia l was ex t rac ted by ho t perco la t ions and dr ied under vacuum to remove t races o f the so lven t . The y ie lds were 18% w/w and 6.1% w/w for water and methanol ic ex t rac t s respec t ive ly . The HPTLC ana lys i s revea led the p ...

The present study was conducted to investigate the lipid-lowering and antioxidative activities of Ocimum sanctum L. (OS) leaf extracts in liver and heart of rats fed with high-cholesterol (HC) diet for seven weeks. The results shows that OS suppressed the high levels of serum lipid profile and hepatic lipid content without significant effects on fecal lipid excretion. Fecal bile acids excretion...

We have investigated the antinociceptive effects of the essential oil of Ocimum gratissimum L. (Labiatae) (EOOG) in two classical models of pain in male Swiss mice (25-35 g), the writhing test and the formalin test. At doses of 30, 100 and 300 mg/kg (po), EOOG produced a dose-dependent inhibition (from 58.3 4.4 to 40.7 6.3, 36.4 3.6 and 24.6 3.6, respectively; N = 8-10, P<0.05) of aceti...

Methanolic extracts of Pterocarpus marsupium Roxb (P. marsupium) and Ocimum sanctum Linn (O. sanctum) were prepared separately and then administered to both non-diabetic and alloxan induced diabetic adult female Wistar rats as a mixture of both at a dosage of 500mg/kg body weight, and its effect was checked on serum and tissue lipids together with corticosterone, estrogen and progesterone profi...

Callus cultures from stem of O. sanctum were induced on slightly modified Murashige and Skoog's (MS) medium and supplemented with 2,4-dichlorophenoxyacetic acid (2,4-D, 1-2 ppm) and kinetin (kn, 1 ppm). Different extractives of stem, leaf and stem callus of O. sanctum were tested for anticonvulsant activity against standard drug phenytoin using maximal electroshock (MES) model. Ethanol and chlo...

Tulsi or Holy Basil (Ocimum sanctum Linn) is a medicinally important plant. Ursolic acid (UA) and oleanolic acid (OA) are among its major constituents which account for many medicinal activities of the plant. In the present work, we deployed a new ambient ionization method, leaf spray ionization, for rapid detection of UA, OA and their oxidation products from tulsi leaves. Tandem electrospray i...

In the present study, a hydroalcoholic extract of ocimum sanctum leaves has been investigated for its antioxidant activity in animal models of peptic ulcer with the aim of exploring a possible correlation between its antioxidant and antiulcer activities. Gastric ulcers were produced in rats by ethanol treatment and pyloric ligation whereas duodenal ulcers were produced in guinea pigs by histami...

1 Department of Botany, Jomo Kenyatta University of Agriculture and Technology, P.O. Box 62000, Nairobi, Kenya. 2 Department of Chemistry, Egerton University, P.O. Box 536, Njoro, Nakuru, Rift Valley, Kenya. 3 Department of Biochemistry, Egerton University, P.O. Box 536, Njoro, Nakuru, Rift Valley, Kenya. 4 Kenya Agricultural Research Institute, P.O. Njoro, Nakuru, Kenya. 5 Department of Botany...