this paper presents a new mathematical model for a bi-objective job shop scheduling problem with sequence-dependent setup times that minimizes the weighted mean completion time and the weighted mean tardiness time. for solving this multi-objective model, we develop a fuzzy multi-objective linear programming (fmolp) model. in this problem, a proposed fmolp method is applied with respect to the o...

Abstract Finding the optimal size of a hybrid renewable energy system is certainly important. The problem often modelled as an multi-objective optimization (MOP) in which objectives such annualized cost, loss power supply probability etc. are minimized. However, MOP model rarely takes load characteristics into account. We argue that ignoring may be inappropriate when designing HRES for place wi...

The present paper deals with a multiobjective optimization of truss topology by either Sequential Linear Programming (SLP) method or Linear Programming (LP) method. The ground structure approach is often used to solve this kind of design problems. In this paper, the topology optimization is formulated as a Multiobjective Optimization Problem (MOP), which is to find the cross-sectional area of t...

The weighted sums approach for linear and convex multiple criteria optimization is well studied. The weights determine a linear function of the criteria approximating a decision makers overall utility. Any efficient solution may be found in this way. This is not the case for multiple criteria integer programming. However, in this case one may apply the more general e-constraint approach, result...

BACKGROUND/AIMS 8-Methoxypsoralen (8-MOP), a formerly considered photosensitizing agent, induces apoptosis when used alone. On this basis, the present study was designed to explore the effects and mechanisms of 8-MOP-induced apoptosis in human hepatocellular carcinoma HepG2 cells, independent of its photoactivation. METHODS We analyzed the cell viability with MTT assay. Flow cytometry was use...

Myeloperoxidase (MOP) is present in monocyte and neutrophil lysosomes, catalyzing hydrogen peroxide and chloride ion conversion to hypochlorous acid. MOP seems to destroy pathogens during phagocytosis by neutrophils and is considered an important defense against innumerous bacteria. We present a patient who had MOP deficiency, who presented with a subacute form of paracoccidioidomycosis and lat...

Endosomal trafficking of signaling proteins plays an essential role in cellular homeostasis. The seven-pass transmembrane protein Frizzled (Fz) is a critical component of Wnt signaling. Although Wnt signaling is proposed to be regulated by endosomal trafficking of Fz, the molecular events that enable this regulation are not completely understood. Here we show that the endosomal protein Myopic (...

Sustainability in agricultural is determined by aspects like economy, society and environment. Multi-objective programming (MOP) model has been a widely used tool for studying and analyzing the sustainability of agricultural system. However, optimization models in most applications are forced to use data which is uncertain. Recently, robust optimization has been used as an optimization model th...

Recently, MOEA/D (multi-objective evolutionary algorithm based on decomposition) has achieved great success in the field of evolutionary multi-objective optimization and has attracted a lot of attention. It decomposes a multi-objective optimization problem (MOP) into a set of scalar subproblems using uniformly distributed aggregation weight vectors and provides an excellent general algorithmic ...