The vehicle routing problem with simultaneous pickup and delivery (VRPSPD) is a well-known combinatorial optimization problem which addresses provided service to a set of customers using a homogeneous fleet of capacitated vehicles. The objective is to minimize the distance traveled. The VRPSPD is an NP-hard combinatorial optimization problem. Therefore, practical large-scale instances of VR...

Objective: This study was conducted to investigate the effectiveness of education based of the cognitive, metacognitive, and behavioral model on the reduction of meta-worry beliefs in patients with social anxiety disorder (SAD). Methods: The research was a quasi-experimental study with pretest-posttest design and a control group. The statistical population comprised all patients with SAD refer...

The use of meta-heuristic optimization methods have become quite generic in the past two decades. This paper provides a theoretical investigation to find optimum design parameters of the Stirling heat engines using a recently presented nature-inspired method namely the gray wolf optimization (GWO). This algorithm is utilized for the maximization of the output power/thermal efficiency as well as...

In this paper, we propose an energy-efficient mathematical model for the resource-constrained project scheduling problem to optimize makespan and consumption of energy, simultaneously. In the proposed model, resources are speed-scaling machines. The problem is NP-hard in the strong sense. Therefore, a multi-objective fruit fly optimization algorithm (MOFOA) is developed. The MOFOA uses the VIKO...

Cross docking is a logistics strategy that strives to reduce inventory holding costs, shipping costs, and delays in delivering the products. In this research, an optimization model is presented for split loading and unloading products by suppliers and customers, vehicle routing with fuzzy possibilistic time window constraints among them, assignment of vehicles to cross dock, consolidation and i...

From the most important issues in the design of large logistics network in times of crisis are providing a timely quick reaction for treating of injured people and the rapid distribution of medicines and medical equipment. In this paper, a multi-objective model is presented that aims to determine the location of transfer points and hospitals to provide timely quick reaction for treating injured...

BACKGROUND Risk of bias (ROB) may threaten the internal validity of a clinical trial by distorting the magnitude of treatment effect estimates, although some conflicting information on this assumption exists. OBJECTIVE The objective of this study was evaluate the effect of ROB on the magnitude of treatment effect estimates in randomized controlled trials (RCTs) in periodontology and implant d...

Objective: We performed this systematic review and meta-analysis study to determine saffron (Crocus sativus) effectiveness and safety in male infertility problems. Materials and Methods: The databases PubMed, Scopus, Cochrane, Google Scholar, SID, IranMedex and Magiran until July 2016 and reference section of relevant articles, were searched to find both English and Persian clinical trials on m...