There has been significant interest in identifying alternative cell sources and growth factor stimulation to improve matrix synthesis for disc repair. Recent work identified nasoseptal chondrocytes (NC) as a possible source with matrix-forming abilities. While various factors such members of the TGFβ superfamily have explored enhance formation, no consensus exists optimum needed induce cells to...

The ability of the nucleus pulposus of the intervertebral disc to resist compressive loads is due to its high content of the proteoglycan aggrecan. Degeneration of the intervertebral disc is preceded and accompanied by a loss of aggrecan due to proteolysis. Biological repair of intervertebral disc degeneration should strive to restore aggrecan content to its optimal functional level. One approa...

Many of the therapeutic interventions for intervertebral disc degeneration attempt to repopulate the nucleus pulposus (NP) tissue; however, NP cells are heterogeneous and not well characterized. To address this, we have investigated the morphology, extracellular gene and protein expression, and apoptosis changes in NP explants cultured in vitro with or without chondrogenic reagents for differen...

Intervertebral disc degeneration is accompanied by elevated levels of inflammatory cytokines that have been implicated in disease etiology and matrix degradation. While the effects of inflammatory stimulation on disc cell metabolism have been well-studied, their effects on cell biophysical properties have not been investigated. The hypothesis of this study is that inflammatory stimulation alter...

Hernia nucleus pulposus adalah suatu kondisi yang dimana terjadi penonjolan pada annulus fibrosus ke dalam lumen kanalis vertebralis sehingga robek karena cakram intervertebralis degeneratif. Kombinasi muscle extension strength exercise dengan kinesiotapping metode lama dikembangkan untuk pemberian treatment kemudian diaplikasikan pasien hernia pulposus. Penelitian ini bertujuan mengetahui perb...