objective(s): accumulating evidence has demonstrated that mirnas contribute to various genetic and epigenetic modifications in the pathogenesis of gastric cancer (gc). recent studies focused on the four single nucleotide polymorphisms (snps) of pre-mirnas including rs11614913, rs3746444, rs2910164, and rs2292832. it was suggested that these four snps were significantly associated with the risk ...

conclusions in general, our study suggests that the association between lep/lepr and ghrl/ghsr with overweight/obesity and the related metabolic disturbances is inconclusive. these results may be due to unidentified gene-environment interactions. more investigations are needed to further clarify this association. results the most prevalent leptin/leptin receptor genes (lep/lepr) and ghrelin/ghr...

Background Obesity is a very common disorder resulting from an imbalance between food intake and energy expenditure, and it has a substantial impact on the development of chronic diseases. The aim of this study was to examine the association of INSIG2 (rs7566605) gene polymorphism with obesity and obesity associated phenotypes in North Indian subjects. Methods The variants were investigated ...

staphylococcus aureus carrying pvl gene remain major health problem associated with highly virulent infections. characterization of such gene is important to know the impact and the functional significance of nucleotide variations. pcr and standard sequencing were performed for twelve sudanese strains from different sources. protein structures prediction, modeling and physiochemical analysis we...

Non-alcoholic fatty liver disease (NAFLD), the most common form of disease, is now recognized as a major public health problem worldwide. Tumor necrosis factor alfa (TNF-α), member TNF/TNFR cytokine family, an intercellular transmission molecule that has been reported in wide range human noninfection diseases. The aim study was to determine circulating levels TNF-α and nature its relationships ...