Clonal expansions of cytotoxic T cells exist in the blood of patients with Waldenström macroglobulinemia but exhibit anergic properties and are eliminated by nucleoside analogue therapy Jia Li,1 Daniel M.-Y. Sze,1-3 Ross D. Brown,2 Mark J. Cowley,4 Warren Kaplan,4,5 Sui-Lin Mo,1,6 Shihong Yang,2 Esther Aklilu,2 Karieshma Kabani,2 Yen S. Loh,1 Tetsuo Yamagishi,1 Yuling Chen,1,5 P. Joy Ho,2 and D...

Novel 5'-deoxythreosyl purine phosphonic acid analogues containing a 2'-electropositive moiety such as fluorine atom, were designed and synthesized from commercially available 1,3-dihydroxy acetone. Condensation successfully proceeded from a glycosyl donor 6 under Vorbrüggen conditions and cross-metathesis gave the desired phosphonate analogues 7a, 7b, 17a and 17b. The synthesized nucleoside ph...

Efforts to develop novel, interferon-sparing therapies for treatment of chronic hepatitis C (HCV) infection are contingent on the ability of combination therapies consisting of direct antiviral inhibitors to achieve a sustained virologic response. This work demonstrates a proof of concept that coadministration of the nucleoside analogue MK-0608 with the protease inhibitor MK-7009, both of which...

Lamivudine is an extensively used drug in combinational therapies for treatment of AIDS and hepatitis B. Due to the presence of S, O acetal and stereogenic centres, the synthesis of lamivudine in good enantiomeric yield is a challenge for synthetic chemists. The main focus of this review article is to highlight systematically those few synthetic strategies which are reported in literature since...

Systemic lupus erythematosus (SLE) nephritis often requires treatment with cyclophosphamide, which carries the risk of major side eVects including infection, ovarian failure and bladder malignancy. Therapeutic strategies that would specifically target lymphocytes are appealing. Following the first report of the use of the purine nucleoside analogue cladribine (2-chloro-2’deoxyadenosine), a sele...

The presence of 10 microM dipyridamole in incubation media of L1210/C2 cells decreased initial rates of zero-trans influx of formycin B (FB, 50 microM), a poorly metabolized inosine analogue, from 4.84 pmol/microliters cell water/s to 0.87 pmol/microliter cell water/s. However, after a 5-min interval of uptake, free FB levels in dipyridamole-treated cells were 165 pmol/microliters cell water, 2...