نتایج جستجو برای: nuclear localization

تعداد نتایج: 363249  

2011
Shanping He Kuowei Huang Xu Zhang Xiangchun Yu Ping Huang Chengcai An

BACKGROUND Genetic studies of the Arabidopsis mutant lsd1 highlight the important role of LSD1 in the negative regulation of plant programmed cell death (PCD). Arabidopsis thaliana LSD1 (AtLSD1) contains three LSD1-type zinc finger motifs, which are involved in the protein-protein interaction. METHODOLOGY/PRINCIPAL FINDINGS To further understand the function of LSD1, we have analyzed cellular...

Journal: :The Journal of biological chemistry 1992
D A Fantozzi S S Taylor P W Howard R A Maurer J R Feramisco J L Meinkoth

cAMP-dependent protein kinase mediates a variety of cellular responses in most eukaryotic cells. Many of these responses are cytoplasmic, whereas others appear to require nuclear localization of the catalytic subunit. In order to understand further the molecular basis for subcellular localization of the catalytic subunit, the effect of the heat stable protein kinase inhibitor (PKI) was investig...

Journal: :The Journal of biological chemistry 2012
Chih-Chao Hsu Chang-Deng Hu

Activating transcription factor 2 (ATF2) belongs to the basic leucine zipper family of transcription factors. ATF2 regulates target gene expression by binding to the cyclic AMP-response element as a homodimer or a heterodimer with c-Jun. Cytoplasmic localization of ATF2 was observed in melanoma, brain tissue from patients with Alzheimer disease, prostate cancer specimens, and ionizing radiation...

Journal: :The Biochemical journal 2002
Hiromi Hanaka Takao Shimizu Takashi Izumi

5-Lipoxygenase (5-LO) metabolizes arachidonic acid to leukotriene A4, a key intermediate in leukotriene biosynthesis. To explore the molecular mechanisms of its cell-specific localization, a fusion protein between green fluorescent protein (GFP) and human 5-LO (GFP-5LO) was expressed in various cells. GFP-5LO was localized in the cytosol in HL-60 cells and in both the nucleus and the cytosol in...

Journal: :The Journal of Cell Biology 2001
Renée S. Polizotto Martha S. Cyert

Calcineurin is a conserved Ca2+/calmodulin-specific serine-threonine protein phosphatase that mediates many Ca2+-dependent signaling events. In yeast, calcineurin dephosphorylates Crz1p, a transcription factor that binds to the calcineurin-dependent response element, a 24-bp promoter element. Calcineurin-dependent dephosphorylation of Crz1p alters Crz1p nuclear localization. This study examines...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1997
S Iuchi H Green

Basonuclin is a zinc-finger protein found in basal cells of the epidermis. In human keratinocyte cultures, basonuclin is susceptible to serine-phosphorylation and the addition of the phosphatase inhibitor, okadaic acid, promotes accumulation of basonuclin in the cytoplasm. The region of basonuclin containing the nuclear localization signal of basonuclin is necessary for nuclear localization of ...

2017
Samila Nasrollahi Amit Pathak

Epithelial cell clusters reside in complex extracellular matrices (ECMs) of varying mechanical properties including stiffness, topography, dimensionality, and confinement. Through mechanotransduction, cells sense and translate the mechanical cues presented by the surrounding ECM into biochemical signals, which control fundamental aspects of cell behavior including differentiation, proliferation...

Journal: :Virology 2003
Michael Belshan Lee Ratner

The Vpx protein of human immunodeficiency virus type 2 (HIV-2) is a viral accessory protein related to, but distinct from, the Vpr protein of HIV-1. Vpx is packaged into virions and, as a component of the viral preintegration complex (PIC), Vpx is required for efficient virus replication in nondividing cells. Therefore, the localization of Vpx in cells is dynamic and dependent upon discrete dom...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2006
Ismaël Hervé Koumakpayi Jean-Simon Diallo Cécile Le Page Laurent Lessard Martin Gleave Louis R Bégin Anne-Marie Mes-Masson Fred Saad

PURPOSE The ErbB1 and ErbB2 receptors have been implicated in prostate cancer progression, but less is known about the role and biology of other ErbB receptor family members in prostate cancer. The aim of this study was to analyze the expression and localization of ErbB3 in prostate tissues and prostate cancer cell lines. EXPERIMENTAL DESIGN Immunohistochemistry of ErbB3 was done on prostate ...

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