OBJECTIVE To analyze the efficacy and safety of nonsteroidal anti-inflammatory drugs (NSAID) in the elderly. METHODS We performed a systematic review using a sensitive search strategy. All studies published in MEDLINE (since 1961), EMBASE (since 1961) and Cochrane Library (up to December 2007) were selected. We defined the population (elderly as subjects aged 60 years or above with musculoske...

AIM To investigate the effects of a non-steroidal anti-inflammatory drug (NSAID) ophthalmic solution on latanoprost induced intraocular pressure (IOP) reduction in glaucoma patients. METHODS Examination was conducted on 16 eyes of 16 glaucoma patients who had been given only latanoprost for at least 6 weeks. The NSAID ophthalmic solution, sodium 2-amino-3-(4-bromobenzoyl) phenylacetate sesqui...

BACKGROUND The relationship between hypersensitivity to NSAID and atopic status is still incompletely defined. Previous studies found a high prevalence of atopic diseases in multiple NSAID reactors. The present study aimed to investigate whether this is the case also in Italian adults hypersensitive to NSAIDs. METHODS Skin tests with a large panel of seasonal and perennial airborne allergens ...

Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely used drugs (1). To identify the characteristics of pregnant women who redeemed at least one prescription of an NSAID, we performed a nationwide cohort study including all registered pregnancies resulting in a birth in Denmark from 1997 to 2010. All births were identified using the Medical Birth Registry (2). Information on...

OBJECTIVES The objectives of this study were to (i) survey the risk factors for NSAID gastropathy in outpatients (elderly patients in the community), compared to those living in old people's homes or nursing homes, (ii) study the prescription of medication prophylaxis during use of NSAIDs conform the current national guidelines and (iii) survey the influence on gastrointestinal symptoms and saf...

Pain relieving drugs are one of the most commonly used drugs worldwide either through prescription or as over the counter medication. Non-steroidal anti-inflammatory drugs usually abbreviated as NSAIDs, are the drugs with analgesic, antipyretic and, in higher doses, with antiinflammatory effects. NSAIDs inhibit cyclooxygenase (COX) 1 and 2. So, most of the side effects develop as a result of cy...

BACKGROUND Nonsteroidal anti-inflammatory drugs (NSAIDs) may prevent Alzheimer dementia (AD). METHODS We analyzed the association of prior NSAID exposure with incident dementia and AD in the Adult Changes in Thought population-based cohort aged > or = 65 years (median 74.8) at enrollment. Participants were members of Group Health, which provided computerized pharmacy dispensing records from 1...

Gastrointestinal or cardiovascular complications limit nonsteroidal anti-inflammatory drugs (NSAID) prescription. Glucosamine hydrochloride (GS-HCl) alternatively chosen, but debates still exist in its clinical efficiency. COX-2 instability through inhibiting COX-2 N-glycosylation of GS-HCl raised the possibility of NSAID sparing effect. Study was done to determine whether combination treatment...