Sickle cell anemia (SCA) is a paradigmatic single gene disorder caused by homozygosity with respect to a unique mutation at the b-globin locus. SCA is phenotypically complex, with different clinical courses ranging from early childhood mortality to a virtually unrecognized condition. Overt stroke is a severe complication affecting 6–8% of individuals with SCA. Modifier genes might interact to d...

4,414.329 11/1983 Wegner .............................. 435/7. 4,775,622 10/1988 Hitzeman ........ ... 435/69.4 4,808,537 2/1989 Stroman et al. ........................ 435/6 4,837,148 6/1989 Cregg ................. 4,855,231 8/1989 Stroman et al. 4,882,279 1/1989 Cregg ............................... 435/172.3 4,885,242 12/1989 Cregg ................................. 435/69.1 4,895,800 1/1990 ...

51) Int. Cl." ...................... C12P 21/00; C12N 15/00; C12N 1/00; A61K 39/00 52 U.S. Cl. ................................... 435/68; 435/172.3; 435/253; 435/317; 514/8; 514/12; 530/350; 530/351; 530/395; 530/808; 424/85; 424/88; 536/27 58) Field of Search ................... 435/68, 70,240, 243, 435/253, 172.3, 317; 514/12, 8; 260/112.5 R; 935/9, 11-13, 65; 536/27; 424/88, 85; 530/350, 35...

[54] MICROORGANISMS HAVING MULTIPLE COMPATIBLE DEGRADATIVE ENERGY-GENERATING PLASMIDS AND PREPARATION THEREOF [75] Inventor: Aanada M. Chakrabarty, Latham, N.Y. [73] Assignee: General Electric Company Schenectady, N.Y. [21] Appl. No.: 207,563 [22] Filed:....................................... Jan. 7, 1972 [51] Int. Cl. .....................................C12N 15/00 [52] US Cl. ..........435/17...

Azelaic acid (AzA) and its derivatives have been known to be effective in the treatment of acne and various cutaneous hyperpigmentary disorders. The esterification of azelaic acid with lauryl alcohol (LA) to produce dilaurylazelate using immobilized lipase B from Candida antarctica (Novozym 435) is reported. Response surface methodology was selected to optimize the reaction conditions. A well-f...

6,123,819 A * 9/2000 Peeters ....................... 204/452 6,361,958 B1 * 3/2002 Shieh et al. ................. 435/7.1 6,524,790 B1 * 2/2003 Kopf-Sill et al. .............. 435/6 6,585,939 B1 7/2003 Dapprich 6,599,436 B1 7/2003 Matzke et al. 6,613,512 B1 9/2003 Kopf-Sill et al. 6,649,358 B1 * 11/2003 Parce et al. .................. 435/7.2 6,699,665 B1 * 3/2004 Kim et al. ......................

1120-6721/435-07$25.00/0 © Wichtig Editore, 2008 PURPOSE. To evaluate the influence of posterior capsular opacification (PCO) on macular optical coherence tomography (OCT) imaging quality and measurements of macular retinal thickness. METHODS. In this prospective interventional case series, 32 eyes of 23 patients with PCO were recruited. Best-corrected visual acuity (BCVA), a complete ophthalmo...

12 The selective acylation of multifunctional compounds exhibiting both alcohol and amino 13 groups gives interesting products with many applications in food, cosmetic and 14 pharmaceutical industries, but it is real challenge. The current work describes the different 15 behavior shown by Candida antarctica lipase B (Novozym 435) when catalyzing the O-16 acylation and N-acylation of bifunctiona...

Objective Glucose 6-phosphate dehydrogenase (G6PD) deficiency increases the risk of neonatal hyperbilirubinemia. The aim this study is to evaluate factors associated with hyperbilirubinemia in infants from western part Guangdong Province, and assess contribution G6PD jaundice. Methods term People's Hospital Yangjiang June 2018 July 2022 were recruited for retrospective analysis. All underwent q...