نتایج جستجو برای: notch depth
تعداد نتایج: 179341 فیلتر نتایج به سال:
BACKGROUND Lung cancers are resistant to conventional chemotherapeutic interventions such as paclitaxel. Notch signaling is crucial in the chemoresistance of lung cancer cells. The Notch inhibitor gamma-secretase inhibitor (GSI) inhibits the Notch signaling pathway. MATERIAL AND METHODS Here, we evaluated how Notch-3 inhibition by GSI can enhance the sensitivity of lung cancer cells to paclitax...
sudden fracture is one of the major failure modes in brittle materials. plexiglass (polymethyl methacrylate) is a well known brittle polymer, widely used in various industries. many types of notches, particularly v-shaped notches, are sometimes used in the components made of plexiglass. these notches can dramatically decrease the load bearing capacity of components due to the concentration of s...
High expression of Notch-1 and Jagged-1 mRNA correlates with poor prognosis in breast cancer. Elucidating the cross-talk between Notch and other major breast cancer pathways is necessary to determine which patients may benefit from Notch inhibitors, which agents should be combined with them, and which biomarkers indicate Notch activity in vivo. We explored expression of Notch receptors and liga...
AIMS Notch and activin receptor-like kinase 1 (ALK1) have been implicated in arterial specification, angiogenic tip/stalk cell differentiation, and development of arteriovenous malformations (AVMs), and ALK1 can cooperate with Notch to up-regulate expression of Notch target genes in cultured endothelial cells. These findings suggest that Notch and ALK1 might collaboratively program arterial ide...
این پژوهش سعی بر آن داشت تا سه کتاب رایج آموزش زبان انگلیسی در موسسات اصفهان را مورد ارزیابی قرار دهد. به این منظور، ابتدا پیمایشی انجام شد که نشان داد سه کتاب four corners،top notchو interchange بیشتر از دیگرکتابهای موجود در بازار مورد استقبال و استفاده این موسسات قرار گرفته اند. پس از انتخاب کتابها برای ارزیابی، این پژوهش در دو مرحله انجام گرفت. در مرحله اول، برای تعیین ملاک های ارزیابی سه کت...
Notch and the DSL Notch ligands Delta and Serrate/Jagged are glycoproteins with a single transmembrane domain. The extracellular domain (ECD) of both Notch receptors and Notch ligands contains numerous epidermal growth factor (EGF)-like repeats which are post-translationally modified by a variety of glycans. Inactivation of a subset of genes that encode glycosyltransferases which initiate and e...
Two glycosyltransferases that transfer sugars to EGF domains, OFUT1 and Fringe, regulate Notch signaling. However, sites of O-fucosylation on Notch that influence Notch activation have not been previously identified. Moreover, the influences of OFUT1 and Fringe on Notch activation can be positive or negative, depending on their levels of expression and on whether Delta or Serrate is signaling t...
Mammalian Notch receptors contain 29-36 epidermal growth factor (EGF)-like repeats that may be modified by protein O-fucosyltransferase 1 (Pofut1), an essential component of the canonical Notch signaling pathway. The Drosophila orthologue Ofut1 is proposed to function as both a chaperone required for stable cell surface expression of Notch and a protein O-fucosyltransferase. Here we investigate...
The trans-admittance-mode (TAM) might act as a transforming bridge for voltage-mode to current-mode conversion. In this study a new low voltage operated electronically tunable TAM biquad filter structure realizing all the seven standard filtering functions namely; low-pass (LP), band-pass (BP), high-pass (HP), regular-notch (RN), low-pass-notch (LPN), high-pass-notch (HPN) and all-pass (AP) fro...
In this paper, accumulation of plastic deformation of AISI 1045 steel plates with circular cutouts under cyclic axial loading is studied. Loading was applied under force-control conditions. Experimental tests were performed using a Zwick/Roell servo hydraulic machine. Under force-control loading with nonzero mean force, plastic strain was accumulated in continuous cycles called ratcheting. Nume...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید