OBJECTIVE The present study tested the hypothesis that gestational hypoxia up-regulates protein kinase C (PKC) and inhibits calcium-activated potassium channels (KCa)-mediated relaxations of uterine arteries in pregnancy. STUDY DESIGN Uterine arteries were isolated from nonpregnant (NPUA) and pregnant (PUA) (~140 day gestation) sheep maintained at either sea level or high altitude (3,820 m fo...

Acute mountain sickness (AMS) strikes those in the mountains who go too high too fast. Although AMS has been long assumed to be due solely to the hypoxia of high altitude, recent evidence suggests that hypobaria may also make a significant contribution to the pathophysiology of AMS. We studied nine healthy men exposed to simulated altitude, normobaric hypoxia, and normoxic hypobaria in an envir...

To investigated whether an acute hypoxic stimulus affects muscle strength development assessed by isokinetic dynamometry during maximal knee extension. A total of 15 healthy young men participated in this study (61.9 ± 6.1 kg; 1.72 ± 0.08 m; 20.9 ± 2.6 years). We evaluated knee extension and flexion isokinetic dynamometer performance in normoxic and hypoxic conditions. The analyzed parameters, ...

Chronic hypoxia increases endothelial nitric oxide synthase (eNOS) production of nitric oxide (·NO) and cardioprotection in neonatal rabbit hearts. However, the mechanism by which this occurs remains unclear. Recent studies suggest that heat shock protein 90 (hsp90) alters eNOS function. In the present study, we examined the role of hsp90 in eNOS-dependent cardioprotection in neonatal rabbit he...

introduction: the purpose of this work was to study the ability of mri normoxic polymer gel dosimetry for evaluating the dose distribution in hdr brachytherapy of esophagial cancer at imam reza brachytherapy center (mashhad, iran). materials and methods: initially, 2liters of normoxic gel (magic) was fabricated and then poured into 12 calibration test tubes and placed in a perspex walled phanto...

Klinger, James R., Rod R. Warburton, Linda A. Pietras, Oliver Smithies, Richard Swift, and Nicholas S. Hill. Genetic disruption of atrial natriuretic peptide causes pulmonary hypertension in normoxic and hypoxic mice. Am. J. Physiol. 276 (Lung Cell. Mol. Physiol. 20): L868–L874, 1999.—To determine whether atrial natriuretic peptide (ANP) plays a physiological role in modulating pulmonary hypert...