OBJECTIVE To assess the absorption profile of inhaled insulin in healthy, actively smoking subjects at baseline, after smoking cessation, and after smoking resumption and compare it with nonsmoking subjects. RESEARCH DESIGN AND METHODS Insulin pharmacokinetics and glucodynamics were measured in 20 male smoking subjects (10-20 cigarettes/day) and 10 matched nonsmoking subjects after receiving ...

BACKGROUND A smoke-free law came into effect in Spain on 1st January 2006, affecting all enclosed workplaces except hospitality venues, whose proprietors can choose among totally a smoke-free policy, a partial restriction with designated smoking areas, or no restriction on smoking on the premises. We aimed to evaluate the impact of the law among hospitality workers by assessing second-hand smok...

Cigarette smoking produces oxidant-mediated changes in the lung important to the pathogenesis of emphysema. Since vitamin E can neutralize reactive oxygen species and prevent peroxidation of unsaturated lipids, it may constitute an important component of the lung's defense against oxidant injury. To better characterize the antioxidant protective role of vitamin E, young asymptomatic smokers and...

Objective: To determine the association between smoking and in-hospital outcomes in patients presented with ST-Elevation Myocardial Infarction undergoing primary percutaneous coronary intervention (PCI). Methodology: This prospective cohort study was conducted at Department of Cardiology, National Institute Cardiovascular Disease (NICVD), Karachi, from November 9, 2020 to May 8, 2021. All (curr...

Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation. It is most likely the result of complex interactions of environmental and genetic factors. Because pulmonary surfactant components play important roles in normal lung function, innate host defence, and inflammation in the lung, this study investigated the hypothesis that the surfactant protein genes are invol...

The effect of smoking on Assisted Reproductive Technology (ART) results in male was considered as a deleterious factor in pregnancy outcome among IVF patients. Male smoking is associated with lower success rate in ICSI and IVF couples. Smoking significantly decreased live birth rates and has a deleterious effect on sperm’s DNA. This study was designed to evaluate the effect of male cigarettes s...

BACKGROUND No-reflow phenomenon after percutaneous coronary intervention (PCI) in patients with acute ST-segment-elevation myocardial infarction (STEMI) is relatively common and has therapeutic and prognostic implications. Cigarette smoking is known as deleterious in patients with coronary artery disease (CAD), but the effect of smoking on no-reflow phenomenon is less investigated. The aim of t...