One important goal in cardiology is to prevent necrotic cell death in the heart. Necrotic cell death attracts neutrophils and monocytes into the injured myocardium. The consequences are fibrosis, remodelling and cardiac failure. The renin-angiotensin system promotes the development of cardiac failure. Recently, alternative renin transcripts have been identified lacking the signal sequence for a...

The development of gastroenteritis caused by non-typhoidal Salmonella (NTS) is mediated the action effectors that belong to Type three secretory systems (T3SS) enterica. These are expressed pathogenicity islands 1 and 2 located in genome. T3SS-1 provide invasion salmonella into host cell, take part inflammatory diarrhea some may act as a predisposing factor oncogenesis leading colorectal cancer...

BACKGROUND The role of increased insulin resistance in the pathogenesis of type 2 diabetes has been emphasized in Asian populations. Thus, we evaluated the proportion of insulin resistance and the insulin secretory capacity in patients with early phase type 2 diabetes in Korea. METHODS We performed a cross-sectional analysis of 1,314 drug-naive patients with newly diagnosed diabetes from prim...

The transparency of the juvenile zebrafish and its genetic advantages make it an attractive model for study of cell turnover in the gut. BrdU labelling shows that the gut epithelium is renewed in essentially the same way as in mammals: the villi are lined with non-dividing differentiated cells, while cell division is confined to the intervillus pockets. New cells produced in the pockets take ab...

During their synthesis, a large fraction of proteins are directed to the secretory pathway. There are several models that aim to distinguish between different destinations along this pathway, however they rarely distinguish between known stages of this translocation process. This paper presents a translocation probability function which models the protein SRP-recruitment process – the first sta...

The present study has disclosed for the first time the distribution of cytokeratin (CK) and  smooth muscle actin (SMA) in the accessory genital glands of camel. In prostate, CK was localized in the cytoplasm of columnar cells of secretory acini and in the scanty cytoplasm of basal cells. Conversely, no expression was seen in the capsule, fibromuscular septa, and blood vessels. In the ampulla ...

the present study is related to the histochemical investigations on the changes in the intensity of reactions of axons, acid and neutral mucopolysaccharides, biologically active macromolecules, particularly glycogen and protein component as well as alkaline phosphatase (alpase) and adenosine triphosphatase (atpase) in the cells lining the olfactory epithelium of catla catla . the intense reacti...

Most cases of the dominantly inherited movement disorder, early onset torsion dystonia (DYT1) are caused by a mutant form of torsinA lacking a glutamic acid residue in the C-terminal region (torsinADeltaE). TorsinA is an AAA+ protein located predominantly in the lumen of the endoplasmic reticulum (ER) and nuclear envelope apparently involved in membrane structure/movement and processing of prot...

The host defense system with lysozyme and secretory phospholipase A2 (sPLA2) was immunohistochemically investigated in rat respiratory tract under healthy conditions. In the nasal epithelium, a large number of non-ciliated and non-microvillous cells (NC) and a small number of goblet cells (GC) were immunopositive for lysozyme and sPLA2. A few acinar cells and almost all epithelial cells of inte...

BACKGROUND Disorders in immune system regulation may result in pregnancy abnormalities such as recurrent spontaneous abortion (RSA). This study aims to determine the ratio of regulatory T (Treg) and T helper (Th) 17 cells in unexplained RSA (URSA) women during proliferative and secretory phases of their menstrual cycles compared to healthy non-pregnant women. MATERIALS AND METHODS In this cas...