objective(s): to appraise the antihepatotoxic efficacy of ethanolic extract of operculum turpethum root on the liver of swiss albino mice.   materials and methods:   hepatic fibrosis was induced in adult male albino mice through intraperitoneal administrations of n-nitrosodimethylamine (ndma) at the concentration of 10 mg/kg body weight. the liver toxicity and therapeutic effect of the plant et...

The effects of alpha-ketoglutarate (alpha-KG) on sodium valproate-induced hyperammonemia and hepatotoxicity were studied in biochemical experiments in rats. The levels of ammonia, urea, serum transaminases, hydroperoxides and thiobarbituric acid reactive substances were significantly increased in sodium valproate-treated rats. These levels were significantly decreased in alpha-KG- and sodium va...

The effects of -ketoglutarate ( -KG) on ethanol-induced hepatotoxicity were studied in biochemical experiments in rats. The levels of serum transaminases and thiobarbituric acid reactive substances were significantly increased in ethanol-treated rats. These levels were significantly decreased in -KGand ethanol-treated rats. Further, non-enzymatic (vitamins C and E) and enzymatic (superoxide dis...

The effects of alpha-ketoglutarate (alpha-KG) on ethanol-induced hepatotoxicity were studied in biochemical experiments in rats. The levels of serum transaminases and thiobarbituric acid reactive substances were significantly increased in ethanol-treated rats. These levels were significantly decreased in alpha-KG- and ethanol-treated rats. Further, non-enzymatic (vitamins C and E) and enzymatic...

The purpose of this study was to investigate the possible antioxidant effect of metformin in high fructose fed diet-induced diabetic rats. The increased level of lipidperoxidation and altered levels of enzymatic and non enzymatic antioxidants were seen in high fructose fed consumed animals. The administration of metformin significantly normalized the altered levels of lipid peroxidation and ant...

Iron nanoparticles (Fe NPs) have a wide array of biological and medical applications. In agriculture, Fe NPs has the potential to be used as an innovative technique alleviate deficiency in various crops, such grape. However, effect on alleviating stresses grapevine are unexplored. The aim this study was evaluate efficiency protecting ‘Asgari’ seedless grape (Vitis vinifera L.) against oxidative...

of different kinds of diseases, including aging, coronary heart disease, inflammation, stroke, diabetes mellitus, rheumatism, liver disorders, renal failure and cancer. Reactive oxygen species (ROS) comprise free radicals such as · O2 (superoxide anion), · OH (hydroxyl radical), H2O2 (hydrogen peroxide) and O2 (singlet oxygen), which can cause cellular injuries and also initiate peroxidation of...

ISSN:0975-1459 Oxidative stress plays an important role in the pathogenesis of some diseases such as lung cancer, chronic obstructive pulmonary disease, and atheroscleorosis. Smoking may enhance oxidative stress not only through the production of reactive oxygen radicals in smoke but also through weakening of the antioxidant defense systems. Cigarette smoke may promote atherogenesis by producin...

BACKGROUND The association between hypertension and diabetes has been linked to increased oxidative stress with age. This study was to examine the level of age-dependent alterations in antioxidant defense system between patients having hypertension and/or type-2 diabetes. METHODS The study was conducted at the Ahmadu Bello University Teaching Hospital, Zaria-Nigeria, using 200 Subjects recrui...