BACKGROUND AND AIMS Manual laboratory continuous positive airway pressure (CPAP) titration for obstructive sleep apnoea (OSA) is costly, time intensive and delays access to treatment. Automatic positive airway pressure (APAP) titration has the potential to reduce cost and improve access to treatment. The aim of this study was to assess the clinical efficacy and costs of APAP titration compared ...

Single-cell experiments show that gene expression is stochastic and bursty, a feature that can emerge from slow switching between promoter states with different activities. In addition to slow chromatin and/or DNA looping dynamics, one source of long-lived promoter states is the slow binding and unbinding kinetics of transcription factors to promoters, i.e. the non-adiabatic binding regime. Her...

A new Al(III) selective membrane based on 5-bromo(salicylidene-2-amino thiophenol) as a neutral carrier in a poly(vinyl chloride) (PVC) matrix is coated on platinum wire to determine trace amounts of Al(III) ion in various samples. The sensor exhibits a good response for Al(III) ion over a wide concentration range of 5.20 × 10-7 to 1.00 × 10-2 M  with Nernstian slope of 19...

Acid or base concentrations can be determined by performing an acid-base titration with OHor H+ ions, coulometricaliy generated by the electrolysis of water at a noble metal actuator electrode. This can be done very rapidly if the actuator electrode is in close proximity to an ISFET which is used as the indicator electrode to detect the equivalence point in the titration curve. In order to rest...

• Complex formation of poly(2-ethyl-2-oxazoline) and poly(N-vinylpyrrolidone) with molecular iodine has been studied in aqueous solutions. Poly(2-ethyl-2-oxazoline) exhibits greater ability to bind compared Iodophors based on exhibited similar antimicrobial properties. Formation iodophors by interactions dissolved solutions addition potassium iodide ethanol using a range physicochemical techniq...

a new al(iii) selective membrane based on 5-bromo(salicylidene-2-amino thiophenol) as a neutral carrier in a poly(vinyl chloride) (pvc) matrix is coated on platinum wire to determine trace amounts of al(iii) ion in various samples. the sensor exhibits a good response for al(iii) ion over a wide concentration range of 5.20 × 10-7 to 1.00 × 10-2 m  with nernstian slope of 19.64 ± 0.15 mv decade-1...

Corresponding Author: Allen B. King, M.D., C.D.E., Diabetes Care Center, 1260 S. Main, Salinas, CA 93901; email address [email protected] In clinical trials in which once-daily basal insulin is titrated to fasting plasma glucose (FPG) targets, the goal is usually reached before the end of the study. After reaching the goal but before the end of the study and if the titration is conti...

The synthesis and photophysical properties of the Eu(iii) complex , based on the use of 1,10-phenanthroline (phen) as a combined sensitizing antenna and a transition metal ion coordinating ligand, is described. The long-wavelength Eu(iii) emission from this complex was found to be highly pH sensitive, giving rise to a 'off-on-off' pH profile with maximum emission occurring within the physiologi...