The aim of the present study was to investigate the association between polymorphism in the interleukin-10 gene promoter at position -1082 in human immunodeficiency virus-infected patients who had presented allergic reaction due to efavirenz. The study included 63 patients treated at the Hospital São José de Doenças Infecciosas, Fortaleza, Ceará, Brazil. Twenty-one patients who had presented al...

This new regular feature will be focusing on the different methodologies used in the diagnosis of allergies, describing current assays and introducing novel approaches. Hypersensitivity reactions can be differentiated into IgEand non-IgE-mediated allergic but also non-allergic reactions. Over the next issues the different in vitro and in vivo diagnostic assays will be explained and the advantag...

Cases of rhinitis can be divided into allergic and non-allergic and salient features from the history usually enable your patient to be assigned to one of these two categories. Allergic rhinitis is suspected when there is family history of atopic illnesses or when a child with rhinitis has co-existent asthma or atopic dermatitis. Seasonality of symptoms, provocation of symptoms by exposure to a...

Background: Allergic conjunctivitis (AC) represents one of most the common condition presented in a paediatric age group. It is usually underdiagnosed and undertreated, especially non-verbal group patients. However, some cases presenting can become reason patients were coupled with lack verbal complain parents’ role management, lead to poorer prognosis. Case: A 7-year-old girl whos under invest...

The high affinity IgE receptor, Fc epsilonRI, plays a key role in the immunological pathways involved in allergic asthma. Previously we have demonstrated that human neutrophils isolated from allergic asthmatics express a functional Fc epsilonRI, and therefore it was of importance to examine the factors regulating its expression. In this study, we found that neutrophils from allergic asthmatics ...

BACKGROUND Even though thymic stromal lymphopoietin (TSLP) has been implicated in the development of allergic inflammation, its influence on immune tolerance mediated by regulatory T cells (Treg) have not been explored. We aimed to dissect the influence of TSLP on immunosuppressive activities of Treg and its potential consequences in human allergic asthma. METHODS In vitro culture system was ...