Ludmila Boudová, M. D., Emina Torlakovic, M. D., Jan Delabie, M.D., Peter Reimer, M.D., Beate Pfistner, Ph. D., Sabine Wiedenmann, M. D., Volker Diehl, M.D., Hans-Konrad Müller-Hermelink, M. D., Thomas Rüdiger, M. D. Department of Pathology, Charles University, Pilsen, Czech Republic, Department of Pathology, The Norwegian Radium Hospital, Oslo, Norway, 3 Medizinische Poliklinik, University of ...

INTRODUCTION Paraneoplastic neuropathies are rare. They are often difficult to diagnose, especially when they precede the diagnosis of cancer. Hodgkin's lymphoma is associated with multiple paraneoplastic neurological syndromes, of which demyelinating polyneuropathies are very unusual. Association with chronic inflammatory demyelinating polyneuropathy is even more uncommon. CASE PRESENTATION ...

The pathogenesis of Hodgkin lymphoma (HL) is still largely unknown. Based on a search for footprints of pathogenetic mechanisms in global RNA expression data of Hodgkin/Reed-Sternberg (HRS) cell lines, we analyzed the expression and activation of 6 receptor tyrosine kinases (RTKs) in classic HL. Immunohistochemistry revealed that the RTKs platelet-derived growth factor receptor A (PDGFRA), DDR2...

We report 22 cases of Hodgkin lymphoma involving Waldeyer ring seen at our institution during a 31-year interval. There were 16 males (73%) and 6 females (27%) with a median age of 48 years (range, 5-81 years), and 15 (68%) patients had airway obstruction or tonsillar enlargement. For 19 patients, the clinical stage was as follows: I, 7 (32%); II, 11 (50%); and III, 1 (5%). The 3 patients (14%)...

background and objectives: human herpes 6 virus (hhv-6) could remain latent and chronic in the host cells after primary infection. hhv-6 genome encodes certain trans activation proteins which may results in development of malignantlymphoma. the association of human herpes six virus (hhv-6) infection and hodgkin and non-hodgkin lymphomas is strongly supported by epidemiological studies. the aim ...

A three-year-old boy presented with an enlarging neck mass. Biopsy demonstrated IgD-positive nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL), which was staged as IIa. The patient received cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) with rituximab and had excellent results. NLPHL is a relatively rare disease that is biologically distinct from classic Hodgkin lymphom...

A 7-year-old castrated male ferret developed unilateral cervical lymphadenomegaly over a 1-month period. Histological examination revealed proliferation of tumor cells in a diffuse and partially nodular pattern. The tumor cells were predominantly Hodgkin cells and binucleated Reed-Sternberg cells, characterized by abundant, clear, vacuolated cytoplasm, pleomorphic, ovoid nuclei with thick nucle...

lymphomas are solid malignant tumors having a wide spectrum of clinical and pathological features. non-hodgkin’s lymphoma (nhl) is a subtype of lymphoma with two-thirds of the cases presenting as lymph node enlargement. the remaining one third of nhl cases has been reported in the extranodal sites, including the gastro intestinal tract, waldeyer’s ring, bone, skin, and brain. intraoral non-hodg...

A 39-year-old previously healthy woman presented with intractable progressive headache and blurred vision over 1 month. Neurologic examination had normal results. Brain neuroimaging showed multiple extra-axial masses and diffuse smooth and nodular thickening and enhancement of the dura of the posterior fossa (figure 1). Pathologic findings of the dura were diagnostic of mucosa-associated lympho...