Arginine is a semi-essential amino acid that plays a critical role in several metabolic pathways. The best known of these is as the immediate precursor of urea in the liver and to a lesser extent in the intestine.1 The enzyme responsible for the cleavage of arginine to produce urea is arginase, which is the only enzyme in the urea cycle that comes in two forms, arginase I, a cytosolic enzyme, a...

NO produced by endothelial NO synthase (NOS3) decreases sodium transport by the thick ascending limb (THAL). We found previously that 7 days of high salt (HS) increased THAL-NOS3 expression but not NO production. NOS3 phosphorylation regulates enzyme activity. We hypothesized that HS acutely increases NOS3 expression and NO production, and, over time, changes in NOS3 phosphorylation dissociate ...

Excess nitric oxide (NO) induces apoptosis of some cell types, including macrophages. As NO is synthesized by NO synthase (NOS) from arginine, a common substrate of arginase, these two enzymes compete for arginine. There are two known isoforms of arginase, types I and II. Using murine macrophage-like RAW 264.7 cells, we asked if the induction of arginase II would downregulate NO production and ...

Nitric oxide (NO), previously known as Endothelium-Derived Relaxing Factor (EDRF) is involved in a wide range of physiological and pathophysiological mechanisms. It is synthesized endogenously by the enzymes Nitric Oxide Synthase (NOS) in specialized tissues from its precursor L-arginine, yielding L-citrulline as a byproduct. It is released by a family of isoenzymes, viz., the endothelial (eNOS...

this research was conducted to determine the effect of gamma ray (gr) (100 and 150 kgy), sodium hydroxide (50 g/kg dm) and calcium oxide (160 g/kg dm) on gas production parameters and in vitro digestibility of soybean straw. all treatments, except for the gamma ray (100 and 150 kgy) did not have gas production up to 4 hours after incubation and there was a lag time. from 8 to 96 hours of incuba...

An (m,m,m)-array of order n is an n×n array such that each cell is assigned a set of at most m symbols from {1, . . . , n} such that no symbol occurs more than m times in any row or column. An (m,m,m)-array is called avoidable if there exists a Latin square such that no cell in the Latin square contains a symbol that also belongs to the set assigned to the corresponding cell in the array. We sh...

Nitric oxide (NO), previously known as Endothelium-Derived Relaxing Factor (EDRF) is involved in a wide range of physiological and pathophysiological mechanisms. It is synthesized endogenously by the enzymes Nitric Oxide Synthase (NOS) in specialized tissues from its precursor L-arginine, yielding L-citrulline as a byproduct. It is released by a family of isoenzymes, viz., the endothelial (eNOS...