Supplemental Methods Neonatal ischemia-reperfusion. All experiments complied with ethical guidelines of Robert Debré Hospital Research Council Review Board (A75-19-01), INSERM and the ARRIVE guidelines (http://www.nc3rs.org/ARRIVE). Ischemia was induced in Wistar P7 rat pups (1618 g; Janvier, Le Genest St-Isle, France; both sexes) and was adapted to isoflurane anesthesia . Briefly, thermoregula...

a Research Institute of the Hospital 12 de Octubre (“i + 12”), Madrid, Spain b Research Institute “Dr. Viña Giner”, Molecular and Mitochondrial Medicine, Catholic University of Valencia San Vicente Mártir, Valencia, Spain c School of Medicine, Catholic University of Valencia San Vicente Mártir, Valencia, Spain d Human Performance Laboratory, MAPEI Sport Research Center, Italy e Department of Ph...

The overwhelming majority of studies that have found increased cancer risk associated with functional deficits in DNA repair used a case-control design, in which measurements were made after cancer diagnosis. However, there are concerns about whether the cancer itself or cancer treatment affected the conclusions (reverse causation bias). We assessed the effect of cancer diagnosis among 26 breas...

Bilirubin induced brain damage is still a common cause of morbidity and mortality in Nigerian infants. No much success has been recorded in decades despite the fact that brain damage from bilirubin toxicity in the newborn is easily preventable with affordable and effective means. We report a case of a newborn with acute bilirubin encephalopathy. This case was considered of interest because the ...

An (m,m,m)-array of order n is an n×n array such that each cell is assigned a set of at most m symbols from {1, . . . , n} such that no symbol occurs more than m times in any row or column. An (m,m,m)-array is called avoidable if there exists a Latin square such that no cell in the Latin square contains a symbol that also belongs to the set assigned to the corresponding cell in the array. We sh...

Inhibition of nitric oxide synthesis (NOS) induces hypertension and heavy proteinuria. Renal structure and function have shown striking improvement after interventions targeting ANG II or endothelin (ET) receptors in rats recovering after long-term NOS inhibition. To search for mechanisms underlying losartan-assisted regression of renal disease in rodents, we measured NO release and contractili...

Ames and his co-workers (Ames et al., 1968; Cantu et al., 1969) observed in rabbits that periods of cerebral ischaemia (circulatory arrest) of more than five minutes were followed by multifocal deficits in brain reperfusion as assessed by the post-ischaemic, intra-arterial injection of a suspension of carbon black. These zones of non-perfusion increased in number and size with increasing length...

Motivated by a congestion problem arising in a Chinese hospital, an M/Ek/1 queueing system, where the service process is subject to no damage interruptions has been considered. When the first phase of service is completed, the service process can be interrupted with probability 1 − p (0 ≤ p ≤ 1) as a result of the customer leaving the service area to attend to otherwork. There is a finite space...

and the staffs at the Federal Reserve Board and the Federal Reserve Banks of Boston, New York, and Philadelphia for helpful comments. The views expressed here are those of the authors and do not necessarily reflect those of the Federal Reserve Bank of Philadelphia or the Federal Reserve System. Abstract This paper conducts an in-depth analysis of structured finance asset-backed securities colla...

OBJECTIVE Our aim was to determine if NO prevents mitochondrial oxidant damage by mobilizing intracellular free zinc (Zn(2+)). METHODS Zn(2+) levels were determined by imaging enzymatically isolated adult rat cardiomyocytes loaded with Newport Green DCF. Mitochondrial membrane potential (DeltaPsi(m)) was assessed by imaging cardiomyocytes loaded with tetramethylrhodamine ethyl ester (TMRE). ...