primary growth hormone insensitivity syndrome (ghis) is a rare entity which can be due to defects in growth hormone (gh) receptor that is called type 1 laron syndrome (t1ls) or post receptor defects (type 2 laron syndrome ). the aim of study was determining the clinical and hormonal milieu of the patients with primary ghis and their response to igf-i (insulin like growth factor-i) generation te...

Neste trabalho preparamos nanopartículas lipídicas sólidas (NLS) a base da manteiga de Cupuaçu (Theobroma grandiflorum) para o carreamento do extrato aquoso polpa açaí (Euterpe oleracea) e camu-camu (Myrciaria florinda). As NLS foram obtidas pela técnica cisalhamento ultrassom caracterizadas Espalhamento Luz Dinâmico (DLS), termogravimetria (TG-DSC) microscopia eletrônica Varredura (MEV). propr...

The correct localization of nuclear proteins is essential for proper growth and development of a eucaryotic cell. Nuclear protein import is a multistep process that eventually results in transport of the polypeptide from its cytoplasmic location of synthesis into the nucleus (for a recent review see Silver, 1991). The translocation into the nuclear interior occurs at the nuclear pore (Feldherr ...

The 289 residue nuclear oncoprotein encoded by the adenovirus 5 Ela gene contains two peptide sequences that behave as nuclear localization signals (NLS). One signal, located at the carboxy terminus, is like many other known NLSs in that it consists of a short stretch of basic residues (KRPRP) and is constitutively active in cells. The second signal resides within an internal 45 residue region ...

The focusing cubic NLS is a canonical model for the propagation of laser beams. In dimensions 2 and 3, it is known that a large class of initial data leads to finite time blow-up. Now, physical experiments suggest that this blow-up does not always occur. This might be explained by the fact that some physical phenomena neglected by the standard NLS model become relevant at large intensities of t...

The rogue wave solutions (rational multibreathers) of the nonlinear Schrödinger equation (NLS) are tested in numerical simulations of weakly nonlinear and fully nonlinear hydrodynamic equations. Only the lowest order solutions from 1 to 5 are considered. A higher accuracy of wave propagation in space is reached using the modified NLS equation, also known as the Dysthe equation. This numerical m...

We have begun to dissect the import apparatus of higher plants by examining the specific association of nuclear localization sequences (NLSs) with purified plant nuclei. Peptides to the simian virus 40 (SV40) large T antigen NLS and a bipartite NLS of maire were allowed to associate with tobacco and maize nuclei. Wild-type NLSs were found to compete for a single class of low-affinity binding si...

In a recent article, Novoa, Michinel, and Tomasini derived a Young-Laplace equation to describe a certain class of stationary solutions of the nonlinear Schrödinger equation (NLS) with cubic and quintic nonlinearities [1]. Light beams, therefore, can sometimes take on the attribute of a liquid when propagating in nonlinear media. This occasional liquidlike nature of light was noted by several a...

Although phosphatase and tensin homologue deleted on chromosome 10 (PTEN) localization in the nucleus and cytoplasm is established, the mechanism is unknown. PTEN is a tumor suppressor phosphatase that causes cell cycle arrest and/or apoptosis. Nuclear-cytoplasmic compartmentalization may be a novel mechanism in regulating these events. PTEN does not contain a traditional nuclear localization s...

Characterization of nuclear protein transport in digitonin-permeabilized cells revealed that the number of the nuclear localization signal sequences (NLS) within the transport substrate basically influences the mechanism of the transport reaction. Phycoerythrine-NLS transport substrate carrying a maximum of 4-5 conjugated NLSs/subunit, or Bsp methyltransferase-NLS fusion protein were efficientl...