The objective of this study was to explore whether parental heavy drinking is associated with suicidal behavior in adolescents, and if so, whether this association is stronger among younger adolescents and whether a possible impact of one parent's intoxication adds to that of the other parent. Two cross-sectional school surveys were conducted in 2002 and 2004 in Norway and comprised 11,637 and ...

Upregulation of xanthine oxidoreductase (XOR) increases vascular reactive oxygen species (ROS) levels and contributes to nitroso-redox imbalance. However, XOR can generate nitric oxide (NO) from nitrite, and increased superoxide could inactivate NO formed from nitrite. This study tested the hypothesis that XOR contributes to the cardiovascular effects of nitrite in renovascular hypertension, an...

background: the aim of this study was to evaluate the efficacy of arterial blood gases (abgs) in determining the type of intoxication. methods: medical charts of all patients who had referred to the toxicology ward of baharloo hospital between january 2009 and december 2009 were evaluated. after excluding the patients with multi-drug toxicity, data, including age, sex, type of intoxication (the...

a survey on lead intoxication in lead mine workers was carried out among khanehsorme, lead miners in najafaabad and also in ab-bagh lead miners in shahreza, both located in district of esfahan, iran. the studies were carried out on 62 miners out of 82 employees in khanehsorme, 25 miners out of 27 employees in ab-bagh lead miners and 47 rural inhabitants in the surroundings of mines were selecte...

introduction methanol is a highly toxic substance and methanol poisoning results in severe health situations. methanol poisoning occurs when it is consumed by various methods such as orally, by inhalation, and transdermally. transdermal poisoning is rarely seen and causes severe health complications. conclusions methanol poisoning presents to the emergency department in our country with many di...

We used affective modulation of the eye-blink component of the startle reflex to examine effects of three levels of alcohol intoxication and a no-intoxication control on emotional responses to pleasant, neutral, and unpleasant pictures. Non-problematic student drinkers (n=101; 48 female) were randomly assigned to intoxication groups. Normal inhibition of startle during exposure to pleasant pict...

Vitamin D intoxication remains a challenging problem due to lack of an efficient treatment. Bisphosphonates, inhibitors of osteoclast-mediated bone resorption, however, have been proposed as a safe and effective alternative in the treatment of vitamin D intoxication. We present here two infants with vitamin D intoxication who were successfully treated with alendronate. We propose that oral alen...

RECENT EXPERIMENTAL EVIDENCE suggests that the anion nitrite represents an important storage form of nitric oxide (NO) that subsequently regulates a number of very important physiological activities (2–5, 10). This is a radical concept because nitrite was largely considered to be a biologically inert breakdown product of NO that served no physiological purpose. In fact, circulating nitrite leve...

OBJECTIVE To raise awareness of risk factors for, and symptoms of, lithium intoxication. QUALITY OF EVIDENCE The literature was searched via MEDLINE from January 1970 to December 1999 using the MeSH headings Lithium, Lithium Carbonate, Drug Toxicity, and Aging. Articles were selected based on clinical relevance and design. Most were case reports, case series, or reviews. MAIN MESSAGE A case...

A long-term sodium nitrite infusion is intended for the treatment of vascular disorders. Phase I data demonstrated a significant nonlinear dose-exposure-toxicity relationship within the therapeutic dosage range. This study aims to develop a quantitative systems pharmacology model characterizing nitric oxide (NO) metabolome and methemoglobin after sodium nitrite infusion. Nitrite, nitrate, and m...