Vaccines for drugs of abuse have yet to achieve full clinical relevance, largely due to poor/inconsistent immune responses in patients. The use of multivalent scaffolding as a means to tailor drug-hapten density and clustering was examined in the context of drug-immune response modulation. A modular trivalent hapten containing a diglycine spacer, triAM1(Gly)2, was synthesized and shown to elici...

AM1-type semiempirical quantum chemical calculations were carried out to explain differences in herbicidal activity between certain phenoxyacetic acid derivatives. It was found that the proper orientation and shape of the COOH group and the phenyl moiety both mutually and individually affected the observed activities.

L-phenylalanine (Phe), an essential amino acid, is necessary for the synthesis of proteins such as catecholamine and melanin, also precursor acid L-tyrosine (Tyr). In this paper, optimized structures Phe, were calculated by using semi-empirical models AM1, PM3 MNDO; Density Functional (DFT) at B3LYP Hartreefock methods (HF) with 6-311++G (d,p) level. The energies geometric parameters Kaempferol...

The main purpose of this paper is to study some relevant applications of the results on bialgebras of type one obtained in [AM1] in the framework of abelian braided monoidal categories. Let H be a braided bialgebra in a cocomplete and complete abelian braided monoidal category (M, c) satisfying AB5. Assume that the tensor product commutes with direct sums and is twosided exact. Let M be in HM H...

Meiosis encompasses a large number of dynamic processes. Some of them are biochemical, such as formation and repair of meiotic double-strand breaks, while others are physical in nature, such as homologous chromosome segregation in anaphase I. Plants have been used as model species in meiosis studies for over 80 years. However, the past decade brought a dramatic improvement in the understanding ...

Respiration rates of bacterial cultures can be a powerful tool in gauging the effects of genetic manipulation and environmental changes affecting overall metabolism. We present an optical method for measuring respiration rates using a robust phosphorescence lifetime-based sensor and off-the-shelf technology. This method was tested with the facultative methylotroph Methylobacterium extorquens AM...

The mass spectrometry of a number of 6-substituted coumarins was studied in the context of correlating fragmentation pathways and electronic charges of atoms performed by AM1 semiempirical method. The atomic charges of atoms are found to be good predictors of the fragmentation pathways.