26 expresses the activity as a function of the aminopyridine pK , the interaction energy with the receptor, and a quotient a 27 of partition functions. Molecular quantum similarity theory is introduced in the model to express the activity as a 28 function of the principal components of the similarity matrix for a series of agonists. To validate the model, a set of 29 five active (protonated) am...

Matrix effects (MEs) continue to be an obstacle in the development of the LC-MS/MS method, with phospholipids being the major cause of MEs. Changing the mobile phase has been a common strategy to reduce MEs; however, the underlying mechanism is unclear. "In-source multiple-reaction monitoring" (IS-MRM) for glycerophosphocholines (PCs) has been commonly applied in many bioanalytical methods. "Vi...

In this study, we model extreme rainfall to study the high events in province of South Sulawesi, Indonesia. We investigated effect El Nino Oscillation (ENSO), Indian Ocean Dipole Mode (IOD), and Madden–Julian (MJO) on events. also assume that a location are affected by other nearby locations. Using data from results showed related IOD MJO.

Immune-suppressive cell populations, including Tregs and suppressor monocytes, have been implicated in long-term survival of allografts in both human transplant recipients and animal models. The factors that drive differentiation and function of these cell populations are not completely understood. In this issue, Bézie and colleagues identify IL-34 as an important mediator of allograft toleranc...