Candida albicans biofilms form on indwelling medical devices (e.g., denture acrylic or intravenous catheters) and are associated with both oral and invasive candidiasis. Here, we determined whether surface modifications of polyetherurethane (Elasthane 80A [E80A]), polycarbonateurethane, and poly(ethyleneterephthalate) (PET) can influence fungal biofilm formation. Polyurethanes were modified by ...

The human intestinal fatty acid binding protein 2 (FABP2) mediates fat absorption by binding and intracellular trafficking of long-chain free fatty acids. Studies with knock-out mice and association analysis of polymorphisms revealed that FABP2 is a susceptibility gene for diabetes type 2 and related traits. Relevant FABP2 promoter polymorphisms c.-80_79insT (rs5861422), c.-136_-132delAGTAG (rs...

One of the most interesting results from the NA49 energy scan program at the CERN SPS is an anomalous behaviour of the energy dependence of the 〈K〉/〈π+〉-ratio in central Pb+Pb reactions [1]. Also, results on the energy dependence of K−φ-, Λ-, Λ̄-, andΩ-production have been reported [2, 3, 8]. The question whether all strange particles exhibit rapid changes in their yield relative to pions and wh...

Cardiac abnormalities are one of the most common congenital defects observed in individuals with Down syndrome. Considerable research has implicated both folate deficiency and genetic variation in folate pathway genes with birth defects, including both congenital heart defects (CHD) and Down syndrome (DS). Here, we test variation in folate pathway genes for a role in the major DS-associated CHD...

The crystal of meta-dinitrobenzene, C6H 4(N 02)2> is orthorhombic pyram idal. The dimensions of the un it cell, which contains 4 molecules, are a = 13-3A, 6 = 14*1 A, c = 3-80A and the space group is Pbn. The m ethod of double Fourier series has been applied, and a projection of the electron density on the ab plane has been made. The plane of the benzene ring of the molecule is inclined a t an ...

BACKGROUND & OBJECTIVES Many pharmacologically-relevant polymorphisms show variability among different populations. Though limited, data from Caucasian subjects have reported several single nucleotide polymorphism (SNPs) in folate biosynthetic pathway. These SNPs may be subjected to racial and ethnic differences. We carried out a study to determine the allelic frequencies of these SNPs in an In...

Polymorphisms in folate pathway genes may influence the susceptibility to acute lymphoblastic leukemia (ALL). DNA was isolated from 245 pediatric ALL patients (cases) and from 500 blood bank donors (controls). Polymorphisms in methylene-tetrahydrofolate reductase (MTHFR 677C>T, 1298A>C), methionine synthase (MTR 2756A>G), methionine synthase reductase (MTRR 66A>G), methylenetetrahydrofolate deh...

1 Investment Company Advertising: Target Date Retirement Fund Names and Marketing, Securities Act Release No. 9126 (June 16, 2010) [75 FR 35920 (June 23, 2010)] (‘‘Proposing Release’’). 2 See Default Investment Alternatives Under Participant Directed Individual Account Plans, 72 FR 60452, 60452–53 (Oct. 24, 2007). 3 Morningstar Fund Research, Target Date Series Research Paper: 2013 Survey, avai...

Synthetic biomaterials are considered to be non-immunogenic. Therefore, the role that adaptive immunity may play in the host response to implanted synthetic biomaterials has not been extensively studied. Cardinal features of adaptive immunity include specificity and T cell responses which are greater and more effective with up-regulation of activation receptors upon re-challenge. We compared th...