Citral is a major constituent of Cymbopogon citratus or lemongrass oil. The anti-clastogenic effect of citral (20 mg/kg) was tested against the known mutagens cyclophoshamide, mitomycin-C and nickel metal (NiCl2) in mice. Micronucleus (MN) frequency was evaluated in both bone marrow and peripheral blood erythrocytes. The sampling was done after 24 h, 48 h and 72 h of clastogen treatment. Result...

Heavy metals such as cadmium, arsenic and nickel are classified as carcinogens. Although the precise mechanism of carcinogenesis is undefined, heavy metal exposure can contribute to genetic damage by inducing double strand breaks (DSBs) as well as inhibiting critical proteins from different DNA repair pathways. Here we take advantage of two previously published culture assay systems developed t...

New structure determinations of CuCl2?2H2O and NiCl2?6H2O are reported from 100 K X-ray diffraction experiments using both Mo K? Cu radiation. Combined density functional theory (ORCA) non-spherical atomic scattering factor (NoSpherA2) computations enabled Hirshfeld atom refinements (HAR) custom factors based on accurately polarized electron densities. The water hydrogen atoms could be position...

New carboranyl thioethers 1-MeO(CH2)nS-1,2-C2B10H11 (n = 2, 3) were prepared by the alkylation of trimethylammonium salt 1-mercapto-ortho-carborane with 1-bromo- 2-methoxyethane and 1-bromo-3-methoxypropane, respectively. Their deboronation cesium fluoride in ethanol gave corresponding nido-carboranes Cs[7-MeO(CH2)nS-7,8-C2B9H11] 3). The reactions Cs[7-MeO(CH2)2S-7,8-C2B9H11] various nickel(II)...