نتایج جستجو برای: neutrophil activation

تعداد نتایج: 463084  

Journal: :Annals of the Rheumatic Diseases 2023

Background Neutrophil activation and the generation of neutrophils extracellular traps (NETs) contribute to vascular damage thrombosis in antiphospholipid syndrome (aPS). We reported that Low molecular weight heparin (LMWH) prevent neutrophil induced by P-selectin expressed activated platelets [1, 2] jeopardize healthy subjects ability generate NETs mobilize granule contents [3]. Objectives To ...

Journal: :Inflammation and cell signaling 2014
Fabien Loison Yuanfu Xu Hongbo R Luo

Neutrophils are the first responders of the inflammatory response. They are characterized by their potent cytotoxic content but also by their limited lifetime. This short half-life is thought to be a self-protecting mechanism for the host, as highlighted by the numerous pathologies associated with imbalanced neutrophil survival. Neutrophil spontaneous death is the prototype of programmed cell d...

Journal: :Blood 1990
K L Hartshorn M Collamer M R White J H Schwartz A I Tauber

Neutrophil dysfunction consequent to influenza A virus infection has been described in vivo and in vitro and may contribute to the serious bacterial sequelae which occur in influenza-infected hosts. On the premise that such dysfunction may represent a form of "deactivation," we sought to characterize neutrophil activation by the virus in comparison with other agonists. The virus induces a respi...

Journal: :Metabolism: clinical and experimental 2010
Eva Särndahl Ida Bergström Johnny Nijm Tony Forslund Mauro Perretti Lena Jonasson

The systemic inflammatory activity in patients with stable coronary artery disease (CAD) is associated with a dysregulated cortisol response. Moreover, an aberrant activation status of neutrophils in CAD has been discussed; and the question of glucocorticoid resistance has been raised. The anti-inflammatory actions of glucocorticoids are mediated by annexin-1 (ANXA1). We investigated the expres...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2017
Xu Wang Weiting Qin Xiaohan Xu Yuyun Xiong Yisen Zhang Huafeng Zhang Bingwei Sun

Although the neutrophil recruitment cascade during inflammation has been well described, the molecular players that halt neutrophil chemotaxis remain unclear. In this study, we found that lipopolysaccharide (LPS) was a potent stop signal for chemotactic neutrophil migration. Treatment with an antagonist of the ATP receptor (P2X1) in primary human neutrophils or knockout of the P2X1 receptor in ...

Journal: :Circulation research 2001
T Takahashi F Hato T Yamane H Fukumasu K Suzuki S Ogita Y Nishizawa S Kitagawa

Cytokine activation of vascular endothelial cells renders the hyperadhesiveness for neutrophils. During the processes of inflammation and atherosclerosis, the production of reactive oxygen species by neutrophils contributes to endothelial cell (EC) damage and injury. However, the precise mechanisms for neutrophil activation by ECs remain unknown. Thus, we investigated what kinds of pathophysiol...

Journal: :Infection and immunity 1990
S S Pedersen A Kharazmi F Espersen N Høiby

Alginate, a viscous polysaccharide from mucoid Pseudomonas aeruginosa, may interfere with the host defenses in patients with cystic fibrosis and chronic P. aeruginosa lung infection. The alginate concentration in the sol phase of expectorated sputum was quantitated by a biochemical method and a newly developed enzyme-linked immunosorbent assay. There was a high degree of correlation between the...

Journal: :Journal of leukocyte biology 2013
François Niyonsaba Laurence Madera Nicole Afacan Ko Okumura Hideoki Ogawa Robert E W Hancock

Although HDPs were originally hypothesized to act as antimicrobial agents, they also have been shown to broadly modulate the immune response through the activation of different cell types. We recently developed a series of novel, synthetic peptides, termed IDRs, which are conceptually based on a natural HDP, bovine bactenecin. We showed that IDR-1 and IDR-1002 protect the host against bacterial...

2017
Sheng-Yang Wu Juin-Hua Huang Wen-Yu Chen Yi-Chen Chan Chun-Hung Lin Yee-Chun Chen Fu-Tong Liu Betty A. Wu-Hsieh

Invasive candidiasis is a leading cause of nosocomial bloodstream infection. Neutrophils are the important effector cells in host resistance to candidiasis. To investigate the modulation of neutrophil fungicidal function will advance our knowledge on the control of candidiasis. While recombinant galectin-3 enhances neutrophil phagocytosis of Candida, we found that intracellular galectin-3 downr...

Journal: :Journal of immunology 2014
Carmen W van den Berg Denise V Tambourgi Howard W Clark S Julie Hoong O Brad Spiller Eamon P McGreal

Neutrophil dysfunction, resulting in inefficient bacterial clearance, is a feature of several serious medical conditions, including cystic fibrosis (CF) and sepsis. Poorly controlled neutrophil serine protease (NSP) activity and complement activation have been implicated in this phenomenon. The capacity for excess NSP secretion and complement activation to influence the expression and function ...

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