BACKGROUND According to the Response Assessment in Neurooncology (RANO) criteria, significant nonenhancing signal increase in T2-weighted images qualifies for progression in high-grade glioma (T2-progress), even if there is no change in the contrast-enhancing tumor portion. The purpose of this retrospective study was to assess the frequency of isolated T2-progress and its predictive value on su...

Abstract Based on the EF-14 trial, Tumor Treating Fields (TTFields) therapy is recommended in treatment guidelines for newly diagnosed glioblastoma (GBM). However, real-world data are limited. The non-interventional TIGER study (NCT03258021) will give insight into patients’ decision, TTFields duration and usage, quality of life, overall survival, adverse events (AEs) setting. Subsequently, we h...

Abstract PURPOSE Satisfaction with work-life balance (WLB) is an essential factor for persistent motivation of early career researchers. However, WLB satisfaction in the neuro-oncological landscape not well characterized. We present results interdisciplinary survey focusing on among neuro-oncologists Germany. METHODS The questionnaire was sent to 351 physicians, all whom were members Neuro-onco...

s Neuro-oncology Primary brain tumors in the Eastern province: 3 years data analysis from King Fahd Specialist Hospital, Dammam Mahmoud Taha, King Fahd Specialist Hospital, Dammam, Saudi Arabia Objective: This is a retrospective review of all cases of brain tumors treated at King Fahd Specialist Hospital in Dammam, which is the only Oncology center in the Eastern province. All cases are usually...

The guiding principle of this chapter is the importance of combining traditional morphological data with the recently acquired knowledge on the genetic and epigenetic signalling pathways which drive the evolution of CNS tumors. The official World Health Organization terminology (WHO, 2007) will be used since it is the source of information for neurooncology, neuroradiology, neurosurgery, etc. I...

OBJECT The term "citation classic" has been used in reference to an article that has been cited more than 400 times. The purpose of this study is to identify such articles that pertain to clinical neurosurgery. METHODS A list of search phrases relating to neurosurgery was compiled. A topic search was performed using the Institute for Scientific Information Web of Science for phrases. Articles...

OBJECT This study was undertaken to evaluate the association between age at diagnosis, patterns of care, and outcome among elderly individuals with anaplastic astrocytoma (AA) and glioblastoma multiforme (GBM). Methods Using the Surveillance, Epidemiology and End Results database, the authors identified 1753 individuals with primary GBM and 205 individuals with primary AA (diagnosed between Jun...

OBJECT Glioblastoma is a highly malignant brain tumor, for which standard treatment consists of surgery, radiotherapy, and chemotherapy. Increasing extent of tumor resection (EOTR) is associated with prolonged survival. Intraoperative magnetic resonance imaging (iMRI) is used to increase EOTR, based on contrast enhanced MR images. The correlation between intraoperative contrast enhancement and ...

More than a decade ago, multimodality imaging was introduced into clinical routine with the development of the positron emission tomography (PET)/computed tomography (CT) technique. Since then, PET/CT has been widely accepted in clinical imaging and has emerged as one of the main cancer imaging modalities. With the recent development of combined PET/magnetic resonance (MR) systems for clinical ...