background and objective: deprenyl is a drug for the treatment of parkinson’s disease, where the dopaminergic neurons are the target of this drug. several reports also documented that deprenyl has an effect on the sensory and motor neurons. there are some reports about the mode of action of deprenyl on motoneurons as a neuroprotective agent, while others believe that deprenyl acts as a neurores...

Complexin (Cpx) is a major regulator for Ca(2+)-triggered fast neuroexocytosis which underlies neuronal communication. Many psychiatric and neurological disorders accompany changes in the Cpx expression level, suggesting that abnormal Cpx levels may elicit aberrant cognitive symptoms. To comprehend how the changes in the Cpx level might affect neuronal communication, we investigated Ca(2+)-trig...

Many neurodegenerative diseases fall under the class of known as proteinopathies, whereby structure and localization specific proteins become abnormal. These aberrant often aggregate within cells which disrupts vital homeostatic physiological cellular functions, ultimately contributing to cell death. Although disease research is typically neurocentric, there evidence supporting role non-neurona...

This review focuses on application of two-photon laser scanning microscopy (TPLSM) for in vivo imaging of vascular reactivity, neurovascular communication and as interventional tool for altering vascular and neuronal networks.

Synchronisation has become one of the major scientific tools to explain biological order at many levels of organisation. In systems neuroscience, synchronised subthreshold and suprathreshold oscillatory neuronal activity within and between distributed neuronal assemblies is acknowledged as a fundamental mode of neuronal information processing. Coherent neuronal oscillations correlate with all b...

Pharmacological blockade or genetic knockout of neuronal connexin 36 (Cx36)-containing gap junctions reduces neuronal death caused by ischemia, traumatic brain injury and NMDA receptor (NMDAR)-mediated excitotoxicity. However, whether Cx36 gap junctions contribute to neuronal death via channel-dependent or channel-independent mechanism remains an open question. To address this, we manipulated c...