We studied the influence of glucose/glucose 6-phosphate cycling on glycogen deposition from glucose in fasted-rat hepatocytes using S4048 and CP320626, specific inhibitors of glucose-6-phosphate translocase and glycogen phosphorylase respectively. The effect of amino acids and oleate was also examined. The following observations were made: (1) with glucose alone, net glycogen production was low...

OBJECTIVE Whole-body protein metabolism is abnormal in suboptimally controlled type 2 diabetes and obesity. We hypothesized that glycemia, insulin resistance, and waist circumference modulate these alterations in type 2 diabetes and, to a lesser extent, in individuals without type 2 diabetes. RESEARCH DESIGN AND METHODS In 88 lean and obese subjects without and 40 with type 2 diabetes on an i...

[1] We describe a method for determining net annual biological oxygen production in the euphotic zone of the ocean using remote in situ measurements of oxygen and nitrogen gas. Temperature, salinity, oxygen, and total dissolved gas pressure were measured every 2 hours at 10-m depth on a mooring at the Hawaii Ocean time series during the year 2005. Since dissolved N2 is effectively inert to biol...

Net HCO transport in the rabbit kidney cortical collecting duct (CCD) is mediated by simultaneous H 1 secretion and HCO secretion, most likely occurring in a and b -intercalated cells (ICs), respectively. The polarity of net HCO transport is shifted from secretion to absorption after metabolic acidosis or acid incubation of the CCD. We investigated this adaptation by measuring net HCO flux befo...

Molecular dynamics simulations are carried out to study the thermal and mechanical phenomena of ultra-high heat flux conduction induced by ultrafast laser heating in thin Si films. Nanoscale Si films with various depths in heat flux direction are treated as a semi-infinite model for the study of ultrafast heat conduction. A distribution of internal heat source is applied to simulate the absorpt...

The influence of the overturning circulation on the anthropogenic carbon sink in the North Atlantic is investigated with a simple box model. The net air-sea flux of anthropogenic carbon is the result of two opposing fluxes: one is uptake caused by the disequilibrium between the rapidly rising atmospheric pCO2 and the dissolved carbon content in the ocean, depending mainly on the water exchange ...

The intimate relationship among ventilation, transit-time distributions, and transient tracer budgets is analyzed. To characterize the advective–diffusive transport from the mixed layer to the interior ocean in terms of flux we employ a cumulative ventilation-rate distribution, ( ), defined as the one-way mass flux of water that resides at least time in the interior before returning. A one-way ...