Conduction in the lateral popliteal nerve of the baboon was studied during the course of Wallerian degeneration. Six nerves were examined. In each case the muscle response to nerve stimulation and the ascending nerve action potential were recorded daily until the nerve became inexcitable. The muscle response to nerve stimulation disappeared after four to five days, but ascending nerve action po...

The human ulnar nerve has been stimulated with square-wave pulses of various fixed durations. Measurements were made of the growth of hand myograms compared with elbow neurograms and of hand myograms compared with finger neurograms, for fixed durations of pulses and increasing strength. The effect of blocking sensory action potentials with stimuli of various durations has been investigated, as ...

1. The application of metabolic inhibitors to nerve-muscle synapses on 'white' and 'red' fibres in the retractor unguis muscles of P. americana and B. giganteus resulted in a dramatic increase in the spontaneous miniature potential discharge and was accompanied by a summation of the miniature potentials to form 'composite' potentials. 2. Axon terminals associated with 'white' muscle fibres resp...

The distribution of nitric oxide synthase (NOS) was determined in the gastrointestinal tract of the rainbow trout, Salmo gairdneri. NOS immunoreactivity and the NADPH diaphorase histochemical reaction were co-localized in nerve cells in the myenteric ganglia. However, only about 60% of NADPH diaphorase-stained nerve cells in the vagus nerve trunks were immunoreactive for NOS. Reactive myenteric...

Until recent years it was widely held that damage to part of the nerve supply of a voluntary muscle had a permanent effect and that the surviving nerve fibres were unable to reinnervate muscle fibres deprived of their nerve supply. It was assumed that the only possibility of recovery of power in the muscle was by hypertrophy of muscle fibres whose nerve supply had escaped damage. The problen ha...

Focal destruction of nerve-fibre bundles is one of the pathological common denominators of diseases involving the optic nerve, the optic papilla, or the superficial layer of the retina. Since Bjerrum (i 89 I) and Ronne ( g909, 19 I 3) first identified arcuate defects in the visual field as the perimetric correlates of defects in arcuate nerve fibres of the retina, quantitative perimetric studie...

At late stages of median nerve entrapment in the carpal tunnel there may be total denervation of the thenar muscles. Surface electrodes over the thenar endplate zone may record an initial and predominantly positive "M" response to supramaximal median nerve stimulation. By a combination of techniques, it has been established that this surface positive response originates from surviving lumbrical...

This investigation was aimed at immunohistochemical analysis of potential changes in the enteric nervous system caused by cancer of the large intestine. In this purpose, neurons and nerve fibers of intestinal plexuses containing neuropeptides: vasoactive intestinal peptide (VIP), pituitary adenylate cyclase-activating polypeptide (PACAP) and neuropeptide Y (NPY), in pathologically changed part ...