Silk Fibers has emerged as a versatile biomaterial for regenerative medicine. In article 2203237, Christine Radtke and co-workers use silk-based nerve conduit filled with spider silk fibers to treat rat sciatic defect. The silk-in-silk achieves similar performance the current gold standard, autograft, represents promising approach reconstruction.

The links between neuropathies of the peripheral nervous system (PNS), including Charcot-Marie-Tooth1A and hereditary neuropathy with liability to pressure palsies, and impaired biomechanical and structural integrity of PNS nerves remain poorly understood despite the medical urgency. Here, we present a protocol describing simultaneous structural and biomechanical integrity investigations on iso...

Motor nerves and sensory nerves conduct signals in different directions and function in different ways. In the surgical treatment of peripheral nerve injuries, the best prognosis is obtained by keeping the motor and sensory nerves separated and repairing the nerves using the suture method. However, the clinical consequences of connections between sensory and motor nerves currently remain unknow...

BACKGROUND Some patients with systemic lupus erythematosus have selective loss of small-diameter nerve fibers, while larger nerve fibers are unaffected. OBJECTIVE To determine intraepidermal nerve fiber densities in patients with different chronic inflammatory autoimmune diseases. DESIGN Cross-sectional study. SETTING Stavanger University Hospital, Stavanger, and Haukeland University Hosp...

OBJECTIVE Peripheral neuropathy is the most frequent neurological complication in diabetic patients. The diagnosis is established by both clinical neurological examination and demonstration of reduced epidermal nerve fibers in skin biopsies (1). Whereas the decrease of free nerve endings has been extensively studied in diabetic patients (2,3), no data are available on possible changes of termin...

The density of sympathetic nerve terminals in human superficial temporal arteries from 5 cases at intra- and extracranial bypass surgery was examined with two histochemical methods, one with potassium permanganate fixation and the other with the new monoamine oxidase staining technique. By potassium permanganate fixation, small cored vesicles containing fibers of noradrenergic nerve terminals m...

Here we have investigated the role of the muscle fiber in the maintenance of presynaptic function at frog motor nerve terminals. Muscle fibers were selectively damaged and prevented from regenerating while leaving the motor innervation intact. Presynaptic activity of the resulting target-deprived nerve terminals was assayed using the fluorescent dye, FMl-43. FMI-43 stains nerve terminals in an ...

The transretinal pathway of optic nerve fibers in the retinas of cynomolgus and bonnet monkeys was studied by light microscopy following small intraretinal injections of horseradish peroxidase (HRP). Injections of HRP into nerve bundles at the optic disc labeled a few ectopic ganglion cells, in addition to those in the related retinal sector. Injections into nerve bundles in the retina labeled ...