intraocular metastatic tumors have been increasingly reported in the recent past. unlike choroidal metastasis, metastasis to retina is very rare and so far has been reported in very few case reports only. case presentation : a 56 year-old male who presented with a history of adenocarcinoma of the cecum and underwent lap colectomy for the primary cecal tumor, received adjuvant chemotherapy for a...

in this issue of iranian journal of ophthalmology (irjo) han yue et al1 from china have presented a very interesting investigation on “histopathologic risk factors of retinoblastoma: a retrospective study of 104 enucleated eyes” which we are very grateful of the authors. before indicating few points about this article and their pathologic classification it is worthwhile to mention the “proceedi...

The term thyroid neoplasm incorporates tumors that originate from follicular cells and those arise parafollicular (C cells). Differentiated cancer, which originates cells, includes papillary carcinoma (PTC), (FTC), oncocytic cell (Hürthle), poorly differentiated carcinoma, anaplastic (ATC). PTC tends to have an indolent clinical course with low morbidity mortality. However, this entity has a br...

OBJECTIVE Meningiomas are neoplasms that arise from the meninges of the central nervous system (CNS). They constitute about 25.6% of CNS tumors diagnosed in Egypt. Some morphological variants of meningiomas display aggressive behavior, leading to brain-invasive growth pattern. Although meningiomas are usually treated by complete surgical excision, the risk of postoperative recurrence remains. H...

We sought to retrospectively analyze the outcomes of patients with intraductal papillary mucinous neoplasm (IPMN) at our pancreatic surgery center, and to evaluate the prognostic value of histological subtype.The clinical data of 121 IPMNs treated in our center between 2005 and 2014 were retrospectively analyzed. Pathological slides were thoroughly reviewed by 2 specialized pathologists.Of the ...

cAMP plays a critical role in regulating migration of various cancers. This role is context dependent and is determined by which of the two main cAMP sensors is at play: cAMP-dependent protein kinase or exchange protein directly activated by cAMP (EPAC). Recently, we have shown that the cAMP sensor protein EPAC1 promotes invasion/migration of pancreatic ductal adenocarcinoma (PDA) in vitro. In ...

Low-grade appendiceal mucinous neoplasm (LAMN) is a rare malignancy and found in less than 0.3% of appendectomy specimens. Patients with LAMN can present abdominal pain mimic clinically as appendicitis, intussusception or obstruction, hence high clinical suspicion needed for correct diagnosis management. The exact nature nomenclature these tumors when they disseminate into the peritoneum contro...

UNLABELLED Renal cell carcinoma (RCC) is the most common neoplasm of the adult kidney, and clear cell RCC (ccRCC) represents its most common histological subtype. To identify a therapeutic target for ccRCC, miRNA expression signatures from ccRCC clinical specimens were analyzed. miRNA microarray and real-time PCR analyses revealed that miR-629 expression was significantly upregulated in human c...

BACKGROUND T lymphoma invasion and metastasis 1 (Tiam1) is a potential modifier of tumor development and progression. Our previous study in vitro and in nude mice suggested a promotion role of Tiam1 on invasion and metastasis of colorectal cancer (CRC). In the present study, we generated Tiam1/C1199-CopGFP transgenic mice to investigate the tumorigenetic, invasive and metastatic alterations in ...

OBJECTIVE To study the histomorphological pattern of urothelial tumors of the urinary bladder in Manipur and to evaluate whether any correlation exists between tumor grade and muscle invasion. METHODS A 10 year retrospective study of all consecutive cases diagnosed in the Department of Pathology RIMS - Imphal, between 1st January 2001 to 31st December 2010. RESULTS The study included 26 cas...