Abstract The number of electrodes used to acquire neonatal EEG signals varies between institutions. Therefore, tools for automatic analysis, such as seizure detection algorithms, need be able handle different electrode montages in order find widespread use. aim this study was analyse the effect montage on detector performance. A full 18-channel compared reduced 3- and 8-channel using a convolut...

Neonatal seizures are the most common overt manifestation of neurological dysfunction in the newborn. It may be the first and only manifestation of neurological dysfunction in variety of insults. The reported prevalence is approximately 1.5% and incidence is approximately 0.95–3.5 per 1,000 live births. 1-3 A seizure may arise from varying foci at different times. Not all clinical seizures corr...

Kainate generates in adult hippocampal neurons a seizure but also a massive excitation of interneurons and a dramatic increase of the inhibitory drive that impinges on principal cells. This "overinhibition" is largely mediated by GluR5-containing kainate receptors that are enriched on interneurons. Here, using the neonatal intact hippocampus in vitro and the triple chamber, we first show that t...

Patricia A. Waltman is an associate professor in the school of nursing and a neonatal nurse practitioner at the University of Mississippi Medical Center in Jackson, Miss. She coordinates and teaches in the neonatal nurse practitioner track in the graduate nursing program. tion of antiepileptic drugs by the mother. Status epilepticus is an immediate threat to both mother and fetus and significan...

Therapeutic options currently available for neonatal seizures are still unsatisfactory both in terms of efficacy and of risk for long-term neurotoxicity, even if there is growing recognition of their potential to worsen neurodevelopmental outcome. A recent paper by Slaughter and colleagues entitled "Pharmacological treatment of neonatal seizures: a systematic review" has been published with the...

Electroclinical uncoupling of neonatal seizures refers to electrographic seizure activity that is not clinically manifest. Uncoupling increases after treatment with Phenobarbital, which enhances the GABA(A) receptor (GABA(A)R) conductance. The effects of GABA(A)R activation depend on the intracellular Cl(-) concentration ([Cl(-)](i)) that is determined by the inward Cl(-) transporter NKCC1 and ...

OBJECTIVE To examine the relationship between gestational weight gain and adverse neonatal outcomes among infants born at term (37 weeks or more). METHODS This was a retrospective cohort study of 20,465 nondiabetic, term, singleton births. We performed univariable and multivariable analyses of the associations between gestational weight gain and neonatal outcomes. We categorized gestational w...

OBJECTIVES To study the etiology of remote symptomatic epilepsy with onset in the first 3 years of life. Patients with neonatal hypoglycemic brain injury (NHBI), were further studied for risk factors and clinical features. METHODS The study was conducted at a tertiary pediatric neurology service between May-August 2004. Consecutive patients were recruited prospectively. The probable etiologic...

Seizures in the newborn brain represent a major challenge to neonatal medicine. Neonatal seizures are poorly classified, under-diagnosed, difficult to treat and are associated with poor neurodevelopmental outcome. Video-EEG is the current gold-standard approach for seizure detection and monitoring. Interpreting neonatal EEG requires expertise and the impact of seizures on the developing brain r...