background the rapid emergence of antibiotic resistance, especially broad-spectrum antibiotics, resulted in the avid use of new potent antibiotics. ceftriaxone and ceftazidime, two third-generation cephalosporin, are usually used to manage complicated and uncomplicated infections. the use of cefepime in resistant infections is increasing gradually, which put this potent antibiotic at risk of re...

The infectious diseases caused by multidrug-resistant bacteria pose serious threats to humankind. It has been suggested that an antibiotic targeting LpxC of the lipid A biosynthetic pathway in Gram-negative bacteria is a promising strategy for curing Gram-negative bacterial infections. However, experimental proof of this concept is lacking. Here, we describe our discovery and characterization o...

conclusions this results of the study show that the most contamination in nicus is from gram-negative bacteria and ciprofloxacin is the most effective antibiotic for treatment. thus, the control of infections in nicus in hospitals is very important. results during the seven-month study on 105 samples, including 85 (81%) urine samples and 20 (19%) blood samples, 81 samples (77.1%) were gram-nega...

OBJECTIVES To determine research priorities of infectious diseases physicians for clinician-initiated randomised controlled trials (RCTs). DESIGN, SETTING AND PARTICIPANTS Online survey of infectious diseases physicians in Australia and New Zealand. MAIN OUTCOME MEASURES Research priorities for, and perceived barriers to, clinician-initiated RCTs. RESULTS 122/550 infectious diseases physi...

OXA-48-type ?-lactamases are now routinely encountered in bacterial infections caused by carbapenem-resistant Enterobacterales . These enzymes of high and growing clinical significance due to the importance carbapenems treatment health care-associated Gram-negative bacteria, wide increasing dissemination OXA-48 on plasmids, challenges posed their detection.

conclusions our findings implied that a wide range of bacteria could be involved in creating urinary tract infection in patients referred to a medical laboratory of kashani and hajar hospital in shahrekord, iran. regardless of age, sex and the use of catheter, a wide range of bacteria could be involved in urinary tract infections. patients and methods in this cross-sectional study 147 urine sam...

Antibiotic-resistant bacteria cause more than two million infections per year in the US, resulting in ~23,000 deaths. These infections incur an estimated $20 billion in direct healthcare costs and $35 billion in lost productivity, and these costs are expected to rise rapidly over the next several years. The threat of antibiotic resistance is especially critical in the case of Gram-negative bact...

Antibiotic-resistant bacteria cause more than two million infections per year in the US, resulting in ~23,000 deaths. These infections incur an estimated $20 billion in direct healthcare costs and $35 billion in lost productivity, and these costs are expected to rise rapidly over the next several years. The threat of antibiotic resistance is especially critical in the case of Gram-negative bact...