OBJECTIVES Although necrotizing enterocolitis (NEC) is primarily a disease of prematurity, full-term infants account for approximately 10% of cases. Previous studies have reported conflicting results regarding NEC in full-term (FT) versus preterm (PT) infants. A review of all infants diagnosed with NEC at our institution over the past 3 decades was performed to identify factors associated with ...

BACKGROUND Necrotizing enterocolitis (NEC) is a devastating neonatal gastrointestinal disease that primarily affects premature infants. It is characterized by bowel inflammation and necrosis. In spite of extensive research, there has been little progress in decreasing the incidence or mortality of NEC over the past three decades. The exact etiology of NEC has not been identified. However, it is...

Despite overall decreasedmortality andmorbidity in preterm very low-birth-weight (VLBW:<1,500 g) infants over the past decades, necrotizing enterocolitis (NEC), a devastating emergency intestinal disease in preterm VLBW infants, remains 5 to 6% and even increase despite much effort on peri-postnatal care.1 More worrisome, approximately 20 to 30% of VLBW infants with NECwill die2 and the remaini...

Multiple cell death is involved in ischemic brain injury. Necroptosis, a recently reported cell death, may be the most suitable cell death mechanism in a subpopulation of neurons under ischemic injury. It reported that a small molecule, necrostatin-1 (Nec-1), has a potent inhibitory effect on necroptotic cell death in vivo and in vitro. The aim of the current study was to investigate the role o...

AIM: to evaluate the effectiveness of first-line chemotherapy in patients with colorectal neuroendocrine cancer (NEC). PATIENTS AND METHODS: a retrospective study included metastatic NEC (2000-2020). The main analyzed parameter was response rate treatment according RECIST criteria, depending on regimen used first line. overall survival additional parameter. RESULTS: 27 (13 initial stage IV dise...