Insulin resistance is associated with obesity and may be accompanied by left ventricular diastolic dysfunction and myocardial remodeling. Decreased insulin metabolic signaling and increased oxidative stress may promote these maladaptive changes. In this context, the beta-blocker nebivolol has been reported to improve insulin sensitivity, increase endothelial NO synthase activity, and reduce NAD...

BACKGROUND Coronary slow-flow (CSF) is an angiographic phenomenon characterised by delayed opacification of vessels in the absence of any evidence of obstructive epicardial coronary disease. QT interval dispersion (QTD) reflects regional variations in ventricular repolarisation and cardiac electrical instability and has been reported to be longer in patients with CSF. AIM To examine QT durati...

OBJECTIVE The aim of this study was to evaluate erectile function in males undergoing coronary artery bypass graft (CABG) while on two different adrenoceptor beta-blocker regimens, namely nebivolol and metoprolol. We hypothesize that the negative effects of cardiopulmonary bypass on erectile function may be possibly attenuated by preferring a vasodilating selective β1-blocker, nebivolol, to met...

BACKGROUND Alterations in endothelial function may contribute to increased susceptibility of black Americans to cardiovascular disease. The ability to pharmacologically reverse endothelial dysfunction in blacks was tested with nebivolol, a beta1-selective agent with vasodilating and antioxidant properties. METHODS AND RESULTS The effects of nebivolol on endothelial nitric oxide (NO), superoxi...

The aim of this study was to investigate the effects of the vasodilating β-blocker nebivolol and the cardioselective β-blocker metoprolol succinate on aortic blood pressure and left ventricular wall thickness. We conducted a randomized, double-blind study on 80 hypertensive patients. The patients received either 5 mg of nebivolol or 50 to 100 mg of metoprolol succinate daily for 1 year. Their h...

A simple, selective, rapid, precise and economical reverse phase HPLC method has been developed for the simultaneous estimation of Amlodipine Besylate and Nebivolol hydrochloride in pharmaceutical dosage forms. The method was carried out on a Luna C-18, 5 μ column with a mobile phase consisting of 0.005M ammonium acetate solution, acetonitrile and triethylamine in the ratio 60:40:0.1 (v/v) and ...

BACKGROUND Heart failure (HF) is a common and disabling condition in older people. Randomized clinical trials and meta-analyses have clearly demonstrated that the long-term use of β-Blockers improves the outcome of patients with HF. However, limited data are available on the treatment of older HF patients with preserved ejection fraction (EF). No study has specifically compared the relative eff...

Heart failure is a common and disabling condition with morbidity and mortality that increase dramatically with advancing age. Large observational studies, retrospective subgroup analyses and meta-analyses of clinical trials in systolic heart failure, and recently published randomized studies have provided data supporting the use of beta-blockers as a baseline therapy in heart failure in the eld...

Background—Nebivolol and carvedilol are third-generation -adrenoreceptor antagonists, which unlike classic -blockers, have additional endothelium-dependent vasodilating properties specifically related to microcirculation by a molecular mechanism that still remains unclear. We hypothesized that nebivolol and carvedilol stimulate NO release from microvascular endothelial cells by extracellular AT...

1.0 Abstract: A sensitive and precise stability indicating RP-HPLC method was developed and validated for the simultaneous determination of known related substances, isomer-I(RRT 0.85), isomer-II(RRT 1.13) and other unknown related substances of nebivolol in nebivolol tablets. The chromatographic separation was performed on Hypersil BDS Phenyl (250mm x 4.6mm) 5μm, using isocratic elution of buf...