Abstract Background and Aims Patients with ANCA-associated vasculitis (AAV) undergo immunosuppressive treatment to thwart organ failure avoid relapse. However, the is associated risk of infections malignancy. There are currently no reliable biomarkers which can be used in clinic assess disease activity. Neutrophil extracellular traps containing nuclear (n) and/or mitochondrial (mt) DNA have bee...

One of the most significant indicators affecting male fertility is sperm nuclear and mitochondrial DNA fragmentation index (DFI). damage depends on biotic abiotic factors, leading to oxidative stress (O.S.). This research aimed investigate relationship between dysfunction spermatozoa their biological adequacy. The material was frozen-thawed samples from Ayrshire, Russian Black Pied Holstein, Re...

Little is known about the life history, ecology, and distribution of genus Allopaa (Dicroglossidae) far less recent data are available larvae this taxon. Here, we provide on larval stage hazarensis (Dubois & Khan, 1979) from northern Pakistan based examination three tadpoles. Specimens were obtained two sites in Buner, Khyber Pakhtunkhwa province, Pakistan. Morphological genetic analysi...

The purpose of the study is to elucidate interrelationships and notable correlations among indicators hormonal regulation, immune status, markers neurodegeneration in patients diagnosed with autoimmune thyroiditis. enrolled a total 170 thyroiditis (divided subclinical manifest form). Control group consist 65 people without thyroid pathologies or other diseases. examination cytokine profiles rev...

Single-stranded DNA (SDNA) occurs in high incidence and in greatest concentration in the sera of patients with systemic lupus erythematosus (SLE), where levels as high as 250 mug/ml were observed. SDNA appears to be an imunogen for anti-SDNA antibodies and forms complexes in vivo of both anti-SDNA-SDNA and anti-NDNA-SDNA types, which apparently play a role in the pathogenesis of the glomerulone...

We studied the genetic structure of Trionyx triunguis populations from the Mediterranean and African continent based on mtDNA D-loop (776 bp) and nine microsatellite loci. A total of 102 polymorphic sites and 13 mtDNA haplotypes were described. Nucleotide diversity and haplotypes diversity were 0.047 and 0.974 respectively. Both mtDNA and nDNA supported the existence of two main management unit...

Myopathy, encephalopathy, lactacidosis and stroke-like episodes (MELAS)-syndrome is a heterogeneous respiratory-chain-disorder (RCD) due to point mutations in mitochondrial genes (m.583G>A, m.1642G>A, m.3243A>G, m.3252A>G, m.3260A >G, m.3271T>C, m.3291T>C, m.5814A>G, m.9957T>C, m.13513G>A), due to mtDNA deletions, or due to nDNA mutations, such as in POLG1.1 Like most of the RCDs, MELAS is a mu...

According to the modern fish system, one species of fourhorn sculpin Triglopsis quadricornis lives in Baltic Sea and Arctic waters. In present study, sculpins from White Seas were studied using different methods: morphological analysis establish patterns seismosensory tomography for study cranial bones, X-ray imaging axial skeleton, as well phylogenetic two mtDNA markers (control region CO1) nD...

Programmed cell death (pcd) is thought to occur during the autolysis of xylem vessels. Although several ultrastructural aspects of this differentiation process have been characterized, certain key aspects of this process remain unsolved. Here we demonstrate in pea (Pisum sativum) that nuclei of vessel elements undergoing pcd contain fragmented nDNA. This finding may provide evidence for the act...

Abstract Background and Aims Mitochondrial DNA (mtDNA) abnormalities, as well complex inflammatory processes involved in the pathogenesis of DKD may be detected early course DKD. The aim study was to evaluate a potential relation mtDNA modifications blood urine with podocyte injury proximal tubule (PT) dysfunction type 2 diabetes mellitus (DM) patients. hypothesis according which changes relate...