نتایج جستجو برای: nct
تعداد نتایج: 1013 فیلتر نتایج به سال:
The aim of the study was to determine the predictive role of breast cancer subtypes in the efficacy and prognosis of neoadjuvant chemotherapy (NCT) regimens combining taxanes and anthracyclines.Data from 240 patients with breast cancer who received surgery after 4 to 6 weeks of NCT were retrospectively analyzed. The patients were classified into luminal A, luminal B, HER2 overexpression, and tr...
While recognized as a generally aggressive disease, triple-negative breast cancer (TNBC) is highly diverse in different patients with variable outcomes. In this prospective observational study, we aimed to develop an RNA signature of TNBC patients to improve risk stratification and optimize the choice of adjuvant therapy. Transcriptome microarrays for 33 paired TNBC and adjacent normal breast t...
The aim of this study was to determine the predictive value of the clinical and histopathological characteristics of estrogen receptor (ER)-positive patients treated with dose-dense paclitaxel/carboplatin neoadjuvant chemotherapy (NCT). Pathological complete response (pCR) and the change in tumor size between pre- and post-NCT were used to evaluate the tumor response.85 ER-positive breast cance...
Being a recent new mum I can see this argument from both perspectives,1 and I think it’s unfair to blame organisations such as the National Childbirth Trust (NCT) for new mother neurosis. I was fortunate that I could attend my antenatal classes at my local GP practice, however, I did feel that all of the emphasis was placed on the ‘birthplan’ (which rarely happens) and how ‘easy’ breastfeeding ...
Orthogonal Frequency Division Multiplexing (OFDM) is a well-known modulation technique for transmission of large amount of digital data with high data rate in both wired and wireless communication systems. High peak-to-average power ratio (PAPR) is the main problem of OFDM system which can be improved by using single carrier frequency division multiple access (SC-FDMA) technique. A new scheme u...
γ-Secretase, a multisubunit transmembrane protease comprised of presenilin, nicastrin, presenilin enhancer 2, and anterior pharynx-defective one, participates in the regulated intramembrane proteolysis of Type I membrane proteins including the amyloid precursor protein (APP). Although Aph-1 is thought to play a structural role in the assembly of γ-secretase complex and several transmembrane dom...
BACKGROUND Chronic heart failure (CHF) is associated with a 4-fold increased risk for osteoporotic fractures. Therefore, we sought to identify the pathophysiological link between chronic heart failure and catabolic bone remodeling. METHODS AND RESULTS In a total cohort of 153 subjects (123 patients with CHF, 30 patients with coronary artery disease and preserved cardiac function) as well as m...
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