Interleukin-1 (IL-1) plays a crucial role in the development of the pathophysiological responses to infection and inflammation. However, the relative contributions of IL-1 alpha and IL-1 beta remain to be clarified. IL-1 beta-deficient mice are a powerful tool to investigate the specific role of IL-1 beta in various experimental conditions. In this report, we summarize the response of IL-1 beta...

By a study of the enzymes contained in fibrinous exudates produced by injection of a sterile inflammatory irritant (turpentine) conditions have been found in which each of two enzymes occurs alone. The one, leucoprotease, digests in the presence of alkali; the other, resembling lymphoprotease, digests in the presence of acid, yet both exhibit almost maximum activity in an approximately neutral ...

The changes in protein metabolism of severe childhood malnutrition are generally perceived as a metabolic adaptation to chronic protein undernutrition. However, severe malnutrition is invariably accompanied by infections which also have profound effects on protein metabolism. This study aimed to distinguish the effect of protein undernutrition from that of an inflammatory stimulus on muscle and...