نتایج جستجو برای: natural tregs

تعداد نتایج: 485151  

2014
V Dioszeghy L Mondoulet V Dhelft M Ligouis E Puteaux C Dupont P-H Benhamou

BACKGROUND Allergen-specific immunotherapy favours immune deviation from a Th2 to a Th1 response and increases the number of regulatory T cells (Tregs). Epicutaneous immunotherapy (EPIT) of sensitized mice decreases the clinical and the allergen-specific Th2 responses and increases local and peripheral Foxp3(+) Tregs. OBJECTIVE To investigate the role of Tregs in EPIT and characterize their p...

2015
Toshiharu Onodera Atsunori Fukuhara Myoung Ho Jang Jihoon Shin Keita Aoi Junichi Kikuta Michio Otsuki Masaru Ishii Iichiro Shimomura

Numerous regulatory T cells (Tregs) are present in adipose tissues compared with other lymphoid or non-lymphoid tissues. Adipose Tregs regulate inflammatory state and insulin sensitivity. However, the mechanism that maintains Tregs in adipose tissue remains unclear. Here, we revealed the contribution of adipose tissue macrophages (ATMs) to the induction and proliferation of adipose Tregs. ATMs ...

Journal: :The Journal of clinical investigation 2008
Takuya Ueno Antje Habicht Michael R Clarkson Monica J Albin Kazuhiro Yamaura Olaf Boenisch Joyce Popoola Ying Wang Hideo Yagita Hisaya Akiba M Javeed Ansari Jaeseok Yang Laurence A Turka David M Rothstein Robert F Padera Nader Najafian Mohamed H Sayegh

T cell Ig mucin 1 (TIM-1) plays an important role in regulating immune responses in autoimmune and asthma models, and it is expressed on both Th1 and Th2 cells. Using an antagonistic TIM-1-specific antibody, we studied the role of TIM-1 in alloimmunity. A short course of TIM-1-specific antibody monotherapy prolonged survival of fully MHC-mismatched vascularized mouse cardiac allografts. This pr...

Journal: :Journal of immunology 2009
Luciana L Molinero Jianying Yang Thomas Gajewski Clara Abraham Michael A Farrar Maria-Luisa Alegre

Natural regulatory T cells (nTregs) that develop in the thymus are essential to limit immune responses and prevent autoimmunity. However, the steps necessary for their thymic development are incompletely understood. The CARMA1/Bcl10/Malt1 (CBM) complex, comprised of adaptors that link the TCR to the transcription factor NF-kappaB, is required for development of regulatory T cells (Tregs) but no...

Journal: :Blood 2011
Anandharaman Veerapathran Joseph Pidala Francisca Beato Xue-Zhong Yu Claudio Anasetti

Adoptive transfer of regulatory T cells (Tregs) prevents GVHD in experimental animals. Because antigen activation drives Treg function, we measured the frequency, growth requirements, and function of alloantigen-specific (allospecific) Tregs from human blood. When alloantigen was presented directly, the precursor frequency of allo-specific Tregs in normal individuals was 1.02% (95% confidence i...

2014
Mladen Jergović Krešo Bendelja Anđelko Vidović Ana Savić Valerija Vojvoda Neda Aberle Sabina Rabatić Tanja Jovanovic Ante Sabioncello

BACKGROUND Regulatory T cells (Tregs) play a key role in immune homeostasis in vivo. Tregs have a critical role in preventing the development of autoimmune diseases and defects in Treg function are implicated in various autoimmune disorders. Individuals with posttraumatic stress disorder (PTSD) have higher prevalence of autoimmune disorders than the general population. We hypothesized that war ...

Journal: :Blood 2012
Yong Chan Kim Ravikiran Bhairavabhotla Jeongheon Yoon Amit Golding Angela M Thornton Dat Q Tran Ethan M Shevach

Foxp3(+) regulatory T cells (Tregs) maintain self-tolerance and adoptive therapy, and using Foxp3(+) Tregs has been proposed as treatment for autoimmune diseases. The clinical use of Tregs will require large numbers of cells and methods for in vitro expansion of Tregs are being developed. Foxp3(+) Tregs can be divided into 2 subpopulations based on expression of the transcription factor, Helios...

2012
Yong Chan Kim Ravikiran Bhairavabhotla Jeongheon Yoon Amit Golding Angela M. Thornton Dat Q. Tran Ethan M. Shevach

Foxp3 regulatory T cells (Tregs) maintain self-tolerance and adoptive therapy, and using Foxp3 Tregs has been proposed as treatment for autoimmune diseases. The clinical use of Tregs will require large numbers of cells and methods for in vitro expansion of Tregs are being developed. Foxp3 Tregs can be divided into 2 subpopulations based on expression of the transcription factor, Helios. Foxp3 H...

Journal: :Journal of immunology 2007
Xin Chen Monika Bäumel Daniela N Männel O M Zack Howard Joost J Oppenheim

Although TNF is a major proinflammatory cytokine, increasing evidence indicates that TNF also has immunosuppressive feedback effects. We have demonstrated in this study that, in both resting and activated states, mouse peripheral CD4(+)CD25(+) T regulatory cells (Tregs) expressed remarkably higher surface levels of TNFR2 than CD4(+)CD25(-) T effector cells (Teffs). In cocultures of Tregs and Te...

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