cytokines have been introduced as critical inducers in the development of th subpopulations.cytokines like il-10 are involved in inducing regulatory t cells such as type 1 regulatory t (tr1) cells cells. il-22 is a member of il-10 family of cytokines, and il-28a is a member of ifn-γ family. in this study, cord blood mononuclear cells (cbmc) from normal healthy individuals were isolated by ficol...

Citation: Elkord E (2016) Helios Should Not Be Cited as a Marker of Human Thymus-Derived Tregs. Commentary: Helios and Helios− Cells Coexist within the Natural FOXP3+ T Regulatory Cell Subset in Humans. Front. Immunol. 7:276. doi: 10.3389/fimmu.2016.00276 Helios Should not Be Cited as a marker of Human thymus-Derived tregs. Commentary: Helios+ and Helios− Cells Coexist within the natural FoXP3+...

Regulatory T cells (Treg) are regarded essential components for maintenance of immune homeostasis. Especially CD4(+)CD25(high) T cells are considered to be important regulators of immune reactivity. In humans and rodents these natural Treg are characterized by their anergic nature, defined as a non-proliferative state, suppressive function and expression of Foxp3. In this study the potential fu...

The heterogeneity of CD4+ T cells has been investigated since the late 1970s, when their Th1 and Th2 subsets were coined. Later studies on the cutaneous form of the Leishmaniasis were focused on the experimental models of Leishmania major infection using the susceptible BALB/c and the resistant C57BL/6 mice. At the early 21st century, the regulatory T-cells subpopulation was introduced and its ...

The study is devoted to the assessment of role immune mechanisms in development acute renal failure HFRS. material for was blood 65 patients with HFRS and 17 ALF toxic nature from comparison group as models kidney damage by hantavirus non-infectious genesis 15 clinically healthy subjects control group. Data were obtained that allow us consider cytolytic effects natural killer cells cytotoxic T-...

Natural CD4CD25 regulatory T lymphocytes are key protagonists in induction and maintenance of peripheral T cell tolerance. Their thymic origin and biased repertoire continue to raise important questions on the signals that mediate their development. We validated analysis of MHC class II-capture by developing thymocytes from thymic stroma as a tool to study quantitative and qualitative aspects o...

Human T-lymphotropic virus type I (HTLV-1) is an endemic virus in Iran and other regions that is associated with multiple diseases including adult T-cell leukemia/ lymphoma and a chronic debilitating neuroinflammatory disease, HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HAM/TSP is seen in approximately 2% of HTLV-1-infected people with symptoms such as back pain, weakne...

human t-lymphotropic virus type i (htlv-1) is an endemic virus in iran and other regions that is associated with multiple diseases including adult t-cell leukemia/ lymphoma and a chronic debilitating neuroinflammatory disease, htlv-1-associated myelopathy/tropical spastic paraparesis (ham/tsp). ham/tsp is seen in approximately 2% of htlv-1-infected people with symptoms such as back pain, weakne...