نتایج جستجو برای: nasal drug delivery

تعداد نتایج: 788001  

Journal: :journal of paramedical sciences 0
amir houshang barati department of medical physics, kurdistan university of medical sciences, sanandaj peyman hejazi department of medical physics, semnan university of medical sciences, semnan hadi hasanzadeh department of medical physics, semnan university of medical sciences, semnan

nowadays, developements in nanotechnology have leeds an increased application of this newborn technology in cancer treatment. in this study, a stabilized micelle was developed to load hpd in order to be used in photodynamic treatment of cancer in an animal model. to construct micelles, pluronic p-105 was used and stabilized to encapsulate hpd . this process includes a 24 h polymerization in whi...

Journal: :journal of physical & theoretical chemistry 2011
r. sariri

hydrogels are introduced to modem medicine as novel materials suitable for a variety ofbiomedical applications. studying hydrogels as novel biomaterials has become a fast-developingand exciting research field during the last two decades. these interesting biomaterials have found awide range of application including contact lenses, vehicles for drug delivery and scaffold in tissueengineering and...

2013
Kornkiat Snidvongs Larry Kalish Raymond Sacks Rahuram Sivasubramaniam Daron Cope Richard J Harvey

BACKGROUND Published randomized controlled trials (RCTs) on the efficacy of intranasal corticosteroid (INCS) in chronic rhinosinusitis (CRS) use either nasal delivery (nasal drop or nasal spray) or sinus delivery (sinus catheter or sinus irrigation) in patients with or without sinus surgery. This influences topical drug delivery and distribution. The effect of these factors on the published res...

2012
Shailja singh Sahauran Mohali

Almost 40% of active Pharmaceutical ingredients have low oral bioavailability, high hepatic first-pass metabolism and also less efficient in crossing the blood brain barrier for brain targeting through oral delivery. To overcome this problem the various system such as: nasal spray, gels, emulsions, droplets, suspensions, powders and thermoreversible mucoadhesive gels etc have been studied for n...

Journal: :archives of razi institute 2016
n. mohammadpour dounighi s.a. ., mortazavi1 a. rezaei mokarram h. zolfagharian m.j. alonso

during last two decades, polysaccharides such as alginate (alg) alone and in combination with other biopolymers are widely used in vaccine and drug delivery systems. the aim of the present work was to investigate the potential utility of microparticles made of alginate (alg) as new vehicles for improving nasal vaccine delivery. for this purpose, diphtheria toxoid (dt) was chosen as a model anti...

Journal: :International journal of nanomedicine 2015
Jinxiang Xi Jiayao Eddie Yuan Xiuhua April Si James Hasbany

BACKGROUND Despite the prevalence of rhinosinusitis that affects 10%-15% of the population, current inhalation therapy shows limited efficacy. Standard devices deliver <5% of the drugs to the sinuses due to the complexity of nose structure, secluded location of the sinus, poor ventilation, and lack of control of particle motions inside the nasal cavity. METHODS An electric-guided delivery sys...

2012
Sveinbjörn Gizurarson

The aim of this review is to provide an understanding of the anatomical and histological structure of the nasal cavity, which is important for nasal drug and vaccine delivery as well as the development of new devices. The surface area of the nasal cavity is about 160 cm2, or 96 m2 if the microvilli are included. The olfactory region, however, is only about 5 cm2 (0.3 m2 including the microvilli...

Journal: :Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine 2007
Julia S Kimbell Rebecca A Segal Bahman Asgharian Brian A Wong Jeffry D Schroeter Jeremy P Southall Colin J Dickens Geoff Brace Frederick J Miller

Many studies suggest limited effectiveness of spray devices for nasal drug delivery due primarily to high deposition and clearance at the front of the nose. Here, nasal spray behavior was studied using experimental measurements and a computational fluid dynamics model of the human nasal passages constructed from magnetic resonance imaging scans of a healthy adult male. Eighteen commercially ava...

A. Rezaei Mokarram H. Zolfagharian M.J. Alonso N. Mohammadpour Dounighi S.A. Mortazavi

  During last two decades, polysaccharides such as alginate (Alg) alone and in combination with other biopolymers are widely used in vaccine and drug delivery systems. The aim of the present work was to investigate the potential utility of microparticles made of alginate (Alg) as new vehicles for improving nasal vaccine delivery. For this purpose, diphtheria toxoid (DT) was chosen as a model an...

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