نتایج جستجو برای: nasal drug delivery
تعداد نتایج: 788001 فیلتر نتایج به سال:
nowadays, developements in nanotechnology have leeds an increased application of this newborn technology in cancer treatment. in this study, a stabilized micelle was developed to load hpd in order to be used in photodynamic treatment of cancer in an animal model. to construct micelles, pluronic p-105 was used and stabilized to encapsulate hpd . this process includes a 24 h polymerization in whi...
hydrogels are introduced to modem medicine as novel materials suitable for a variety ofbiomedical applications. studying hydrogels as novel biomaterials has become a fast-developingand exciting research field during the last two decades. these interesting biomaterials have found awide range of application including contact lenses, vehicles for drug delivery and scaffold in tissueengineering and...
BACKGROUND Published randomized controlled trials (RCTs) on the efficacy of intranasal corticosteroid (INCS) in chronic rhinosinusitis (CRS) use either nasal delivery (nasal drop or nasal spray) or sinus delivery (sinus catheter or sinus irrigation) in patients with or without sinus surgery. This influences topical drug delivery and distribution. The effect of these factors on the published res...
Almost 40% of active Pharmaceutical ingredients have low oral bioavailability, high hepatic first-pass metabolism and also less efficient in crossing the blood brain barrier for brain targeting through oral delivery. To overcome this problem the various system such as: nasal spray, gels, emulsions, droplets, suspensions, powders and thermoreversible mucoadhesive gels etc have been studied for n...
during last two decades, polysaccharides such as alginate (alg) alone and in combination with other biopolymers are widely used in vaccine and drug delivery systems. the aim of the present work was to investigate the potential utility of microparticles made of alginate (alg) as new vehicles for improving nasal vaccine delivery. for this purpose, diphtheria toxoid (dt) was chosen as a model anti...
BACKGROUND Despite the prevalence of rhinosinusitis that affects 10%-15% of the population, current inhalation therapy shows limited efficacy. Standard devices deliver <5% of the drugs to the sinuses due to the complexity of nose structure, secluded location of the sinus, poor ventilation, and lack of control of particle motions inside the nasal cavity. METHODS An electric-guided delivery sys...
The aim of this review is to provide an understanding of the anatomical and histological structure of the nasal cavity, which is important for nasal drug and vaccine delivery as well as the development of new devices. The surface area of the nasal cavity is about 160 cm2, or 96 m2 if the microvilli are included. The olfactory region, however, is only about 5 cm2 (0.3 m2 including the microvilli...
Many studies suggest limited effectiveness of spray devices for nasal drug delivery due primarily to high deposition and clearance at the front of the nose. Here, nasal spray behavior was studied using experimental measurements and a computational fluid dynamics model of the human nasal passages constructed from magnetic resonance imaging scans of a healthy adult male. Eighteen commercially ava...
During last two decades, polysaccharides such as alginate (Alg) alone and in combination with other biopolymers are widely used in vaccine and drug delivery systems. The aim of the present work was to investigate the potential utility of microparticles made of alginate (Alg) as new vehicles for improving nasal vaccine delivery. For this purpose, diphtheria toxoid (DT) was chosen as a model an...
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