Since the COVID-19 pandemic, development of a non-contact medical robot that prevents infection is increasingly required due to field’s heavy workload and emotional stress. To reduce prevent infection, we propose robotic diagnostic system can be applied conventional otolaryngology clinics. A digital twin model was used leverage initial design optimisation system. The proposed developed based on...

Recent evidence suggests that in vertebrates the formation of distinct neuronal cell types is controlled by specific families of homeodomain transcription factors. Furthermore, the expression domains of a number of these genes correlates with functionally integrated neuronal populations. We have isolated two members of the divergent T-cell leukemia translocation (HOX11/Tlx) homeobox gene family...

Nuclear orphan receptor TLX (NR2E1) functions primarily as a transcriptional repressor and its pivotal role in brain development, glioblastoma, mental retardation and retinopathologies make it an attractive drug target. TLX is expressed in the neural stem cells (NSCs) of the subventricular zone and the hippocampus subgranular zone, regions with persistent neurogenesis in the adult brain, and fu...

An empirical analysis was conducted on the workload of helicopter pilots flying in high-risk flight environments such as ground obstacles and weather effects at low altitudes. To evaluate workload, an independent sample t-test performed using NASA-TLX evaluation method most suitable for aviation field, score calculated by applying analytical stratification (AHP) to compare anal...

TLX is known as the orphan nuclear receptor indispensable for maintaining neural stem cells in adult neurogenesis. We report here that neuroblastoma cell lines express high levels of TLX, which further increase in hypoxia to enhance the angiogenic capacity of these cells. The proangiogenetic activity of TLX appears to be induced by its direct binding to the von Hippel-Lindau protein (pVHL), whi...

OBJECTIVES/HYPOTHESIS Image-guided surgery (IGS) systems are frequently utilized during cranial base surgery to aid in orientation and facilitate targeted surgery. We wished to assess the performance of our recently developed localized intraoperative virtual endoscopy (LIVE)-IGS prototype in a preclinical setting prior to deployment in the operating room. This system combines real-time ablative...