Naringin, a flavanone glycoside extracted from various plants, has a wide range of pharmacological effects. In the present study, we investigated naringin's mechanism of action and its inhibitory effect on lipopolysaccharide-induced tumor necrosis factor-alpha and high-mobility group box 1 expression in macrophages, and on death in a cecal ligation and puncture induced mouse model of sepsis. Na...

Dysfunction in adipocytes is associated with insulin resistance and type 2 diabetes. Diabetes-associated anemia has been reported due to the increased non-enzymatic glycosylation of RBC membrane proteins, which correlates with hyperglycemia. The present study was hypothesized to assess the effect of citrus flavonoids on hematological parameters and adipose tissue interleukin-6 and adiponectin i...

Acetylcholinesterase hydrolyzes the neurotransmitter called acetylcholine and is crucially involved in the regulation of neurotransmission. One of the observable facts in the neurodegenerative disorders like Alzheimer's disease is the decrease in the level of acetylcholine. Available drugs that are used for the treatment of Alzheimer's disease are primarily acetylcholinesterase inhibitors with ...

Haizao Yuhu Decoction (HYD) has been used for approximately 500 years and is well-known in Traditional Chinese Medicine for its efficacy in the treatment of thyroid-related diseases. In this study, a rapid liquid chromatography-tandem mass spectrometry method was developed for the determination of liquiritin, naringin, hesperidin, peimine, liquiritigenin, glycyrrhizic acid, bergapten, nobiletin...

In the course of our screening work for new types of lipase inhibitors, hesperidin was identified as a simple and small molecular weight inhibitor in the peels of Citrus unshiu. Hesperidin inhibited lipase activity from porcine pancreas and that from Pseudomonas, and their IC50 was 32 and 132 micrograms/ml, respectively. Hesperidin, neohesperidin, narirutin, and naringin are known as the main f...

oxidative stress is one of the important causes of the type 1 diabetes induced changes in the sperm quality. bioflavonoids, rutin 10 mg/kg and naringin 10 mg/kg were evaluated for their protective effects on sperm parameters, oxidative stress, and histopathology of type 1 diabetic rats. results demonstrated the reduction in sperm count, sperm motility and vitality in diabetic rats. mass drug ad...

Background and Aims: The object of this study was the investigation central antinociceptive effects naringin as well association stimulation opioidergic, serotonergic, adrenergic, cholinergic (muscarinic nicotinic) receptors to analgesia mice due naringin. Methods: Several intraperitoneal doses (20, 40, 80 mg/kg) were injected into models analyzed via hot-plate (integrated supraspinal response)...

based on the valuable antioxidant activity of citrus fruits, in present study the effect of ‎rootstock and the type of tissue on some fruit quality parameters including phenol, ‎flavonoid, antioxidant and the content of hesperidin and naringin of orange and mandarin ‎was studied. the experiment was conducted as a factorial design based on complete ‎randomized blocks with four replications. resu...

In order to develop a database for flavanones, the dominant flavonoid class in the genus citrus, the relevant scientific literature on flavonoids in grapefruit, lemons, and limes was searched, abstracted, documented, standardized by taxons and units (mg/100 g) and examined for quality. Values for eight flavanones (didymin, eriocitrin, hesperidin, naringin, narirutin, neoeriocitrin, neohesperidi...