Although great promise has been achieved with nanomedicines in cancer therapy, limitations are still encountered, such as short retention time the tumor. Herein, a nanosystem that can modulate particle size situ by near-infrared (NIR) light is self-assembled cross-linking surface-modified poly(lactic-co-glycolic acid) from up-conversion nanoparticle indocyanine green and doxorubicin–nitrobeneze...