We have developed a ratiometric time-gated luminescence sensory system for in vivo imaging of hypochlorous acid (HClO) by preparing a dual-emissive nanoarchitecture of europium- and terbium-complex-modified silica nanoparticles. The design of this nanoarchitecture is based on our new finding that the strong, long-lived luminescence of the β-diketonate-Eu3+ complex can be rapidly and selectively...

Introduction Radiolabeled gold nanoparticles play an important role in biomedical application. The aim of this study was to prepare iodine-131 (131I)-labeled gold nanorods (GNRs) conjugated with cyclic RGD and evaluate its biological characteristics for targeted imaging of integrin αvβ3-expressing tumors. Methods HS-PEG(5000)-COOH molecules were applied to replace CTAB covering the surface of...

Tumor angiogenesis plays very important roles for tumorigenesis, tumor development, metastasis, and prognosis. Targeting T1/T2 dual modality magnetic resonance (MR) imaging of the tumor vascular endothelial cells (TVECs) with MR molecular probes can greatly improve diagnostic sensitivity and specificity, as well as helping to make an early diagnosis of tumor at the preclinical stage. In this st...

Autonomous micromanipulation has been an emerging interest in constructing and assembling microobjects. Manual assembly and manipulation of small-scale objects through teleoperation is possible, however autonomy is necessary for large-volume manipulation and manufacturing. In this study, we discuss a two-dimensional autonomous manipulation system, which is based on an optical microscope and a n...

Bombesin (BBN), an analog of gastrin-releasing peptide (GRP), specifically binds to GRP receptors, which are overexpressed in human prostate cancer (PC). Here, we synthesized a BBN-modified gadolinium oxide (Gd2O3) nanoprobe containing fluorescein (Gd2O3-5(6)-carboxyfluorescein [FI]-polyethylene glycol [PEG]-BBN) for targeted magnetic resonance (MR)/optical dual-modality imaging of PC. The Gd2O...

Abstract TARUMÃ is a multi-technique station at CARNAÚBA (Coherent X-Ray Nanoprobe Beamline) the 4th-generation light source Sirius Brazilian Synchrotron Light Laboratory (LNLS). With tender-to-hard energy range from 2.05 to 15 keV and fully coherent nanoprobe focused via an all-achromatic KB (Kirkpatrick-Baez) optics, it can be used for simultaneous multiple nanoscale X-ray techniques in 2D 3D...

A kind of fluorescent/phosphorescent dual-emissive conjugated polyelectrolyte has been prepared by introducing phosphorescent platinum(ii) porphyrin (O2-sensitive) into a fluorene-based conjugated polyelectrolyte (O2-insensitive), which can form ultrasmall conjugated polymer dots (FP-Pdots) in the phosphate buffer solution (PBS) via self-assembly caused by their amphiphilic structures with hydr...