We describe a 2 ½ year old boy presenting with fever, abdominal pain and splinter haemorrhages of the nails. On further examination there were signs of pneumonia with pleural effusion. This was treated with mini-thoracotomy, drainage and intravenous antibiotics. Further diagnostic workup for underlying causes showed diffuse cystic lung disease, suggestive of Langerhans cell histiocytosis. This ...

Systemic sclerosis (scleroderma, SSc) is an autoimmune disease that targets small and medium-sized arteries and arterioles in the involved tissues, resulting in a fibrotic vasculopathy and tissue fibrosis. Several prominent nail and periungual changes are apparent in scleroderma. Examination of the nail fold capillaries can reveal the nature and extent of microvascular pathology in patients wit...

Yellow nail syndrome (YNS) is an uncommon condition characterized by nail changes, lymphedema, in addition to pulmonary disorders and pleural effusion. Pericarditis and non-cardiac disorders can evolve with pericardial effusions including autoimmune conditions, hypothyroidism, malignancies, tuberculosis, and uremia. A 72-year-old Brazilian woman under treatment for arterial hypertension and hyp...

Yau Ma Tei Dermatology Clinic, 12/F, Yau Ma Tei Specialist Clinic, 143 Battery Street, Kowloon, Hong Kong A 57-year-old Chinese gentleman presented with pruritic skin eruptions located mainly over the shins since childhood. Scratching resulted in skin blister and finally scarring. He also had nail dystrophy over the fingers and toes since childhood. Incisional skin biopsy for histology and elec...

We present a case of a 30-year old female patient presenting with acrocyanosis and nail changes (leukonychia, onycholysis), who has been treated with valproic acid for 3 years. Acrocyanosis, listed in the group of acrosyndromes, is a painless condition, characterized by symmetrical discoloration of various shades of blue colour, localized within the hands, feet and face, often associated with h...

Onychomadesis is a clinical sign of nail plate separation due to transient or permanent arrest of nail matrix activities. Onychomadesis can be considered as a severe form of Beau's line. This condition usually occurs after trauma, causal diseases, or medications, yet it rarely occurs as an idiopathic condition. We report a case of a 38-year-old Thai female who developed recurrence onychomadesis...

To the Editor, Trachyonychia, also known as 20-nail dystrophy or rough nails, is characterized by surface roughness and opacity of the nail due to extensive longitudinal ridging [1–3] . The condition may be idiopathic or associated with eczema, lichen planus, psoriasis, or alopecia areata [1–3] . Although spontaneous resolution can be expected in trachyonychia, aggressive treatments are necessa...

BACKGROUND Longitudinal melanonychia (LM) can be a challenging sign since it may be caused by a wide variety of benign and malignant conditions. Cutaneous melanoma is the most important cause of LM. Objective: We performed this study to examine different aspects of LM in Iran, where cutaneous melanoma is rare. METHODS In this cross-sectional study, we reviewed medical records and pathology re...