Objective(s): The role of N-acetylcysteine (NAC) as an anti-oxidant in attenuating bleomycin-induced pulmonary fibrosis has been reported. However, its effect on parenchymal remodeling via regulating the protease-antiprotease balance is not fully defined. Therefore, the present study was designed to explore the possible role of matrix metalloproteinases (MMP), tissue i...

Background: The purpose of our study was to evaluate an inexpensive and available method to reduce mucous impactions in mechanically ventilated patients.Methods: This randomized clinical trial was conducted on 40 mechanically ventilated patients aged 15-90 years. The patients were randomly allocated into two arms; 20 cases and 20 controls. The cases received N-acetylcysteine via their nebulizer...

Background: The aim of this study was to investigate the protective potency of melatonin, amifostine (WR-2721), and N-acetylcysteine (NAC) when administered intraperitoneally (i.p.) 15 min before 10-Gy single-fraction radiotherapy. Materials and Methods: In this study, 35 female Sprague Dawley rats were divided into five groups of seven rats each. The rats in the control group did not receive a...

We aimed to examine trichotillomania (TTM), a rarely seen disorder, and N-acetylcysteine (NAC), an agent used as a treatment option, in the light of literature in the present study. Trichotillomania is the compulsive urge to pull out one’s own hair persistently and leading to noticeable hair loss. Contrary to what is expected, it is a more frequently detected disorder characterized by compulsiv...

BACKGROUND/AIMS To evaluate the adjuvant effects of N-acetylcysteine (NAC) on first-line sequential therapy (SQT) for Helicobacter pylori infection. METHODS Patients with H. pylori infections were randomly assigned to receive sequential therapy with (SQT+NAC group, n=49) or without (SQT-only group, n=50) NAC. Sequential therapy consisted of rabeprazole 20 mg and amoxicillin 1 g for the first ...

With the development of science and technology, and development of artery bypass, methods such as cardiopulmonary cerebral resuscitation have been practiced in recent years. Despite this, some methods fail to promote or recover the function of tissues and organs, and in some cases, may aggravate dysfunction and structural damage to tissues. The latter is typical of ischemia-reperfusion (IR) inj...

Non-alcoholic fatty liver disease (NAFLD) in children has become the most common liver disease influencing adolescent health and one of the most influencing chronic liver diseases among children in Chinese wealthy families, particularly in coastal regions. However, the medicine available for the treatment of NAFLD is deficient. In order to solve this problem, our team studied the activated carb...

Abstract Introduction: taVNS improves oral feeding in newborns who are failing feeds but is ineffective Infants of Diabetic Mothers (IDM) with lower CNS glutathione(GSH) concentrations a prior trial. We hypothesized that mitigating oxidative stress N-acetylcysteine(NAC) to would enhance motor learning IDM and achieve full feeds. measured PK GSH changes NAC. Methods: Following informed consent, ...

Background and Purpose The pathophysiology of coronary artery spasm (CAS), with its associated ischaemic crises, is currently poorly understood treatment frequently ineffective. In view increasing evidence that platelet-based defects may occur in CAS patients, we investigated platelet reactivity patients whether symptomatic crises reflect activation platelet–endothelial interactions. Experiment...

Background: Despite vast amount of completed and ongoing researches, the role immune system in COVID-19 remains unclear. Widespread lung damage as result disease also often causes pulmonary fibrosis a sequela. Antioxidant property N-Acetylcysteine (NAC) has prompted its use adjuvant therapy COVID-19, both regulation prevention fibrosis. We analyze high dose NAC (>1200 mg/day) response, media...