Abstract Background Elevated lipoprotein(a) [Lp(a)] has been established as marker of cardiovascular [CV] risk, however, it is not commonly assessed. Purpose The aim the study was to characterize patients who underwent their first Lp(a) testing regarding sociodemographic characteristics and clinical outcomes. Methods A retrospective analysis performed on data from 4 million individual in a loca...

Flaviviruses such as dengue virus (DEN) and Japanese encephalitis virus (JEV) are medically important in humans. The lipid kinase, phosphatidylinositol 3-kinase (PI3K) and its downstream target Akt have been implicated in the regulation of diverse cellular functions such as proliferation, and apoptosis. Since JEV and DEN appear to trigger apoptosis in cultured cells at a rather late stage of in...

In this paper, we study algorithmic problems for automaton semigroups and automaton groups related to freeness and finiteness. In the course of this study, we also exhibit some connections between the algebraic structure of automaton (semi)groups and their dynamics on the boundary. First, we show that it is undecidable to check whether the group generated by a given invertible automaton has a p...

Given n points in the plane with nonnegative weights, the inverse Fermat-Weber problem consists in changing the weights at minimum cost such that a prespecified point in the plane becomes the Euclidean 1-median. The cost is proportional to the increase or decrease of the corresponding weight. In case that the prespecified point does not coincide with one of the given n points, the inverse Ferma...

Clostridium botulinum D (strain South Africa) produces ADP-ribosyltransferase which modifies eukaryotic 24-26-kDa proteins. ADP-ribosyltransferase activity was associated with a neurotoxin of 150 kDa (Dsa toxin) as confirmed by the elution profile of Dsa toxin from high performance anion-exchange column. The 24-kDa substrate of Dsa toxin-catalyzed ADP-ribosylation was detected in several tissue...

Let P be a set of n points in general position in the plane, r of which are red and b of which are blue. In this paper we prove that there exist: for every α ∈ [ 0, 1 2 ] , a convex set containing exactly dαre red points and exactly dαbe blue points of P ; a convex set containing exactly ⌈ r+1 2 ⌉ red points and exactly ⌈ b+1 2 ⌉ blue points of P . Furthermore, we present polynomial time algori...

Effects of the tertiary amines, procaine and lidocaine, its quaternary derivative QX—314, and neutral benzocaine, on Na currents in internally perfused neuro-blastoma cells were studied using the suction-pipette voltage clamp technique (Kostyuk et al. 1975 ; Zubov et al. 1980). Neuroblastoma cells used were N18 A-l and NTR-1 subclones derived from C1300 line (Konobasova et al. 1981) and Neuro 2...

Macroscopic Na currents were recorded from N18 neuroblastoma cells by the whole-cell voltage-clamp technique. Inactivation of the Na currents was removed by intracellular application of proteolytic enzymes, trypsin, alpha-chymotrypsin, papain, or ficin, or bath application of N-bromoacetamide. Unlike what has been reported in squid giant axons and frog skeletal muscle fibers, these treatments o...

To the Editor: We describe a 28-year-old man who presented to us with complaints of progressive diminution of vision in both eyes for 2 years. The uncorrected distance visual acuity was 20/200 in both eyes, improving to 20/80 with pinhole. Near vision was N18 in both eyes. Retinoscopy was irregular with an oil-droplet reflex on distant direct ophthalmoscopy. Dilated slit-lamp examination showed...

El objetivo del presente estudio fue identificar el efecto agudo de una sesión Educación Física orientada a la meditación en los niveles estrés escolares 8 12 años., Participaron 34 chilenos, cuales fueron divididos manera aleatoria un grupo experimental (n18) y control (n16). Durante clase realizó mindfulness con duración 15 minutos, mientras hizo encuesta hábitos saludables conducta sedentari...